S100B as marker of brain damage

Authors

  • S. A. Dudukina Mechnikov Dnepropetrovsk Regional Clinical Hospital, Dnepropetrovsk, Ukraine
  • Yu. Yu. Kobelyatskiy Днепропетровск Dnеpropetrovsk State Medical Academy, Dnepropetrovsk, Ukraine

DOI:

https://doi.org/10.25305/unj.88757

Keywords:

brain, damage, diagnostics, protein of S100B

Abstract

The estimation of S100B protein concentration at late time is included to most widespread methods of estimation of brain injury heaviness at neurosurgical and neurological diseases. Of S100B concentration increase in plasma and cerebrospinal fluid is related to microglia activation — the early response of cerebral fabric on damage. S100B level estimation has low specificity, but high sensitiveness for brain damage determination. A change of it’s concentration takes place at intracerebral hemorrhage and ischemic stroke, brain tumors, psychiatric diseases, traumatic brain injury. Protein level measuring in a dynamics gives important information about efficiency of treatment of brain pathology, possible relapse of disease, prognosis.

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Published

2010-03-02

How to Cite

Dudukina, S. A., & Kobelyatskiy, Y. Y. (2010). S100B as marker of brain damage. Ukrainian Neurosurgical Journal, (1), 12–15. https://doi.org/10.25305/unj.88757

Issue

Section

Review articles