S100B as marker of brain damage
DOI:
https://doi.org/10.25305/unj.88757Keywords:
brain, damage, diagnostics, protein of S100BAbstract
The estimation of S100B protein concentration at late time is included to most widespread methods of estimation of brain injury heaviness at neurosurgical and neurological diseases. Of S100B concentration increase in plasma and cerebrospinal fluid is related to microglia activation — the early response of cerebral fabric on damage. S100B level estimation has low specificity, but high sensitiveness for brain damage determination. A change of it’s concentration takes place at intracerebral hemorrhage and ischemic stroke, brain tumors, psychiatric diseases, traumatic brain injury. Protein level measuring in a dynamics gives important information about efficiency of treatment of brain pathology, possible relapse of disease, prognosis.References
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