Activation of regenerative processes optic nerve in traumatic injury under high doses of corticosteroids
DOI:
https://doi.org/10.25305/unj.61883Keywords:
traumatic injury of the optic nerve, regenerative processes, remyelinisation, high doses of corticosteroids, experimentAbstract
Objective: Morphologically justify the effect of high doses of corticosteroids on regenerative processes in the optic nerve (ON) after traumatic injury in the experiment.
Materials and methods: It has been used 6 mature rabbits (Group injured), which made damage the optic nerve. 6 rabbits (treated group) on the second day after the injury were treated with the use administration of methylprednisolone.
Results: The microcirculation of intracranial ON improves observed, accompanied by a decrease in swelling at 14 days after treatment. There was detected remyelinisation regeneration of these fibers. There are young mitochondria in the axoplasma. There were formed microtubules and structured neurofilaments, which is an early sign of regenerative processes of the ON.
Conclusion: Consequently found that for traumatic ON damage high doses of corticosteroids for 14 days results in improvement of microcirculation reduce swelling, remyelinisation and activation of regeneration.
References
1. Ridderstrom M, Ohlsson M. Brilliant blue G treatment facilitates regeneration after optic nerve injury in the adult rat. NeuroReport. 2014;25(17):1405-10. [CrossRef] [PubMed]
2. Gao H, Zhang H, Shou J, Chen L, Shen Y, Tang Q, Huang J, Zhu J. Towards retinal ganglion cell regeneration. Regener Med. 2012;7(6):865-75. [CrossRef] [PubMed]
3. Fitzgerald M, Bartlett C, Harvey A, Dunlop S. Early Events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J Neurotrauma. 2010;27(2):439-52. [CrossRef] [PubMed]
4. Ben Simon G, Hovda D, Harris N, Gomez-Pinilla F, Goldberg R. Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crush. J Neurotrauma. 2006;23(7):1072-82. [CrossRef] [PubMed]
5. Moyseyenko NM, Zhurakivsky AY, Leskiv GN. [Structural changes of the cranial part of the optic nerve in traumatic injury of its orbital part in experiment]. Oftalmologicheskiy zhurnal. 2014;(6):101-5. Ukrainian.
6. Feng D, Chen E, Li X, Liu Y, Wang Y. Standardizing optic nerve crushes with an aneurysm clip. Neurol Res. 2010;32(5):476-81. [CrossRef] [PubMed]
7. Wang X, Li Y, He Y, Liang H, Liu E. A novel animal model of partial optic nerve transection established using an optic nerve quantitative amputator. PLoS ONE. 2012;7(9):865-75. [CrossRef] [PubMed]
8. de Lima S, Koriyama Y, Kurimoto T, Oliveira J, Yin Y, Li Y, Gilbert H, Fagiolini M, Martinez A, Benowitz L. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proceed Nat Acad Sci. 2012;109(23):9149-54. [CrossRef] [PubMed]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Nataliya Moyseyenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.
