The research of sciatic nerve combined plastics efficiency at it’s large defect by it’s functional recovery quantification in rats in experiment




rat’s sciatic nerve, large nerve’s defect, sciatic nerve functional index, autoneuroplastics, tubulization, combined plastics, experiment


Introduction. The aim of the research was sciatic nerve functional recovery quantification at it’s large defect replacement using methods of combined plastics in rats in experiment.

Materials and methods. To control sciatic nerve functional recovery “Walking track analysis” was used.

Results. On the base of 3 main parameters of imprints of soles of hinder legs sciatic functional index (SFI).

Conclusions. 1. The indicators of sciatic nerve functional recovery at it’s defect using combined plastics methods come nearer to results, obtained at nerve’s defect replacement using autoneuroplastics.

2. Sciatic nerve’s functional recovery level at it’s defect do not depends on the variant of combined plastics.

Author Biographies

Vitaliy Tsymbaliuk, Romodanov Neurosurgery Institute, Kiev

Restorative Neurosurgery Department

Ihor Tretyak, Romodanov Neurosurgery Institute, Kiev

Restorative Neurosurgery Department

Aleksandr Gatskiy, Romodanov Neurosurgery Institute, Kiev

Restorative Neurosurgery Department


1. Sarikcioglu L, Demirel BM, Utuk A. Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat. Folia Morphol (Warsz). 2009;68(1):1-7. [PubMed]

2. Tsymbalyuk V I, Stankevich AT. Khirurgicheskoye lecheniye povrezhdeniy perifericheskikh nervov pri bolshikh defektakh [Surgical treatment of peripheral nerve injuries for large defects]. Vracheb. delo. 1987;6:47. Russian.

3. Grigorovich KA. Khirurgicheskoye lecheniye povrezhdeniy nervov [Surgical treatment of nerve injury]. Leningrad: Meditsina; 1981. Russian.

4. Tsymbalyuk VI, Hayko HV, Suliy MM, Strafun SS. Khirurhichne likuvannya ushkodzhen` plechovoho spletennya [Surgical treatment of brachial plexus injury]. Ternopil`: Ukrmedknyha; 2001. Ukrainian.

5. de Olivera ARL, Pierucci A, de Brito Pereira K. Peripheral nerve regeneration through the nerve tubulization technique. Braz. J. Morphol. Sci. 2004;21(4):225–231.

6. Ijpma FF, Van De Graaf RC, Meek MF. The early history of tubulation in nerve repair. J Hand Surg Eur Vol. 2008;33(5):581-586. [CrossRef] [PubMed]

7. Dellon AL, Mackinnon SE. Selection of the appropriate parameter to measure neural regeneration. Ann Plast Surg. 1989;23(3):197-202. [PubMed]

8. Mackinnon S, Hudson A, Hunter D. Histologic assessment of nerve regeneration in the rat.. Plastic and Reconstructive Surgery. 1985;75(3):384-388. [CrossRef] [PubMed]

9. Munro C, Szalai J, Mackinnon S, Midha R. Lack of association between outcome measures of nerve regeneration. Muscle & Nerve. 1998;21(8):1095-1097. [CrossRef] [PubMed]

10. Kanaya F, Firrell J, Breidenbach W. Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration. Plastic & Reconstructive Surgery. 1996;98(7):1264-1271. [CrossRef] [PubMed]

11. MacKinnon S, Dellon A, OBrien J. Changes in nerve fiber numbers distal to a nerve repair in the rat sciatic nerve model. Muscle & Nerve. 1991;14(11):1116-1122. [CrossRef] [PubMed]

12. Urbanchek M, Chung K, Asato H, Washington L, Kuzon W. Rat walking tracks do not reflect maximal muscle force capacity. Journal of Reconstructive Microsurgery. 1999;15(02):143-149. [CrossRef] [PubMed]

13. Gramsbergen A, IJkema-Paassen J, Meek M. Sciatic nerve transection in the adult rat: abnormal EMG patterns during locomotion by aberrant innervation of hindleg muscles. Experimental Neurology. 2000;161(1):183-193. [CrossRef] [PubMed]

14. Woerly S, Petrov P, Syková E, Roitbak T, Simonová Z, Harvey A. Neural tissue formation within porous hydrogels implanted in brain and spinal cord lesions: ultrastructural, immunohistochemical, and diffusion studies. Tissue Engineering. 1999;5(5):467-488. [CrossRef] [PubMed]

15. Johnston R, Zachary L, Lee Dellon A, Seiler W, Teplica D. Improved imaging of rat hindfoot prints for walking track analysis. Journal of Neuroscience Methods. 1991;38(2-3):111-114. [CrossRef] [PubMed]

16. Bain J, Mackinnon S, Hunter D. Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the Rat. Plastic and Reconstructive Surgery. 1989;83(1):129-136. [CrossRef] [PubMed]

17. Carlton J, Goldberg N. Quantitating integrated muscle function following reinnervation. Surg. Forum. 1986;37:611–614.

18. De Koning P, Gispen W. Org.2766 improves functional and electrophysiological aspects of regenerating sciatic nerve in the rat. Peptides. 1987;8(3):415-422. [CrossRef] [PubMed]



How to Cite

Tsymbaliuk, V., Tretyak, I., & Gatskiy, A. (2012). The research of sciatic nerve combined plastics efficiency at it’s large defect by it’s functional recovery quantification in rats in experiment. Ukrainian Neurosurgical Journal, (3), 48–51.



Original articles