Experimental model of intervertebral discs degeneration in rat’s tail


  • Mykhaylo Khyzhnyak Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Valeriy Grigorovsky Institute of Traumatology and Orthopedics, Kiev, Ukraine
  • Yuriy Gafiychuk Military Medical Clinical Center of South Region, Odessa, Ukraine




intervertebral disc, degenerative changes, experimental model


Introduction. Main groups of experimental models of degenerative and trophic changes in intervetebral discs are given.

Materials and methods. An experimental model for study of sequence of degenerative changes forming in intervetebral discs was proposed.

Results. Morphological changes were studied after 30 days and 2 and 3 months. It is established that compression factor plays a key role in degenerative and trophic changes of intervertebral discs.

Conclusions. The obtained results confirm adequacy of the created experimental model of osteochondrosis.

Author Biographies

Mykhaylo Khyzhnyak, Romodanov Neurosurgery Institute, Kiev

Department of Miniinvasive and Laser Spinal Neurosurgery

Valeriy Grigorovsky, Institute of Traumatology and Orthopedics, Kiev

Department of Pathomorphology with Bio-Experimental Unit

Yuriy Gafiychuk, Military Medical Clinical Center of South Region, Odessa

Department of Neurosurgery


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How to Cite

Khyzhnyak, M., Grigorovsky, V., & Gafiychuk, Y. (2012). Experimental model of intervertebral discs degeneration in rat’s tail. Ukrainian Neurosurgical Journal, (2), 58–61. https://doi.org/10.25305/unj.59050



Original articles