Pathomorphological changes of rat’s tail intervertebral disks and vertebrae bodies at asymmetric static compression-distension in the experiment
Keywords:osteochondrosis, intervertebral discs’ degeneration, nucleus pulposus, fibrous ring, chondrocytes, necrosis, notochordal cells
Constant asymmetric static compression-distention (ASCD) of tail segments of the spine was performed in rats by tail stump sewing to its base in the experiment. In period of 1–3 months using histological method it was fixed that ASCD led to pathological changes in intervertebral disks and vertebrae bodies, mainly caused by ischemia and dystrophy. The most constant histologicaly expressed component of intervertebral disks’ damage — is macrofocal cell necrosis in collagen plate of the fibrous ring on the side of compression, accompanied by crumple, significant fiber prevalence and cracking of the plates with perifocal zone of chondrocyte proliferation, but these changed didn’t result in substitution of focal damage in terms of observation. Zones of notochondral cells necrosis were inconstantly noted in the structures of nucleus pulposus and closing plates of vertebrae bodies and small osteomedullary zones of necrosis — in epiphysis and epiphyseal cartilages of the vertebrae bodies. Changes of osseous epiphyses and epiphyseal cartilages height, adjoining to disk in ASCD zones of fibrous ring and also vertebrae bodies marginal ossificates were inconstant and had no correct character.
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Copyright (c) 2011 Valeriy Grigorovsky, Mykhaylo Khyzhnyak, Irina Vasileva, Irina Shuba, Yuriy Gafiychuk
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