Патоморфологические изменения межпозвонковых дисков и тел позвонков хвоста крыс при асимметричной статичной компрессии-дистензии в эксперименте

Valeriy Grigorovsky; Mykhaylo Khyzhnyak; Irina Vasileva; Irina Shuba; Yuriy Gafiychuk

doi:10.25305/unj.57798

Authors

Valeriy Grigorovsky Institute of Traumatology and Orthopedics, Kiev, Ukraine
Mykhaylo Khyzhnyak Romodanov Neurosurgery Institute, Kiev, Ukraine
Irina Vasileva Romodanov Neurosurgery Institute, Kiev, Ukraine
Irina Shuba Romodanov Neurosurgery Institute, Kiev, Ukraine
Yuriy Gafiychuk Military Medical Clinical Center of South Region, Odessa, Ukraine

DOI:

https://doi.org/10.25305/unj.57798

Keywords:

osteochondrosis, intervertebral discs’ degeneration, nucleus pulposus, fibrous ring, chondrocytes, necrosis, notochordal cells

Abstract

Constant asymmetric static compression-distention (ASCD) of tail segments of the spine was performed in rats by tail stump sewing to its base in the experiment. In period of 1–3 months using histological method it was fixed that ASCD led to pathological changes in intervertebral disks and vertebrae bodies, mainly caused by ischemia and dystrophy. The most constant histologicaly expressed component of intervertebral disks’ damage — is macrofocal cell necrosis in collagen plate of the fibrous ring on the side of compression, accompanied by crumple, significant fiber prevalence and cracking of the plates with perifocal zone of chondrocyte proliferation, but these changed didn’t result in substitution of focal damage in terms of observation. Zones of notochondral cells necrosis were inconstantly noted in the structures of nucleus pulposus and closing plates of vertebrae bodies and small osteomedullary zones of necrosis — in epiphysis and epiphyseal cartilages of the vertebrae bodies. Changes of osseous epiphyses and epiphyseal cartilages height, adjoining to disk in ASCD zones of fibrous ring and also vertebrae bodies marginal ossificates were inconstant and had no correct character.

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