Эффективность регионарного введения нитроглицерина для регресса церебрального вазоспазма на экспериментальной модели субарахноидального кровоизлияния

Orest Tsimeyko; L. Senko; Volodymyr Moroz; Ihor Skorochoda

Authors

Orest Tsimeyko Romodanov Neurosurgery Institute, Kiev, Ukraine
L. Senko Romodanov Neurosurgery Institute, Kiev, Ukraine
Volodymyr Moroz Romodanov Neurosurgery Institute, Kiev, Ukraine
Ihor Skorochoda Romodanov Neurosurgery Institute, Kiev, Ukraine

Keywords:

cerebral vasospasm, nitric oxide, nitroglycerin, subarachnoid hemorrhage, intrathecal, angiography

Abstract

The reduction in the level of nitric oxide ( NO) is a purported mechanism of delayed vasospasm after subarachnoid hemorrage (SAH). Evidence in support of a causative role for NO includes the disappearance of nitric oxide synthase (NOS) from the adventitia of vessels in spasm and destruction of NO by hemoglobin released from the clot into the subarachnoid space. The aim was to determine whether a potent vasodilator and donor NO nitroglicerine to Reverse vasospasm in a experimental model SAH in rabbit, when administered through the cerebrospinal fluid to the adventitial side of the constricted blood vessel. The degree of vasospasm in all experiments was assessed by cerebral arteriography. This study indicates that intrathecally administered nitroglycerine is effective in dilation of the spastic artery and in reversing cerebral vasoconstriction in experimental SAH model without any significant changes in the systemic circulation. This method may represent an important therapentic intervention to reverse cerebral vasospasm due to SAH.

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