The effectiveness of the combined treatment of metastatic brain tumors


  • Vladimir Pyatikop Kharkiv National Medical University, Kharkiv, Ukraine
  • Viktor Starenkiy Grigoriev Institute for Medical Radiology, Kharkiv, Ukraine
  • Mohamad Adnan Al-Trawneh Kharkiv National Medical University, Kharkiv, Ukraine
  • Yuri Kotlyarevskiy Kharkiv Regional Clinical Hospital – Center of Emergency Medical Care and Disaster Medicine, Kharkiv, Ukraine
  • Igor Kutovoy Kharkiv National Medical University, Kharkiv, Ukraine



tumor, brain metastasis, neurosurgery treatment, radiation treatment, cytostatic treatment


Aim: Evaluation of effectiveness of radiation therapy (RT) and chemotherapy (CT) of metastatic brain tumors (MBT) in post-operational period.

Materials and methods: 49 patients with MBT were observated: 4 (12,9%) cases — in frontal lobe, 2 (6,5%) — in temporal, 8 (25,8%) — in parietal, 4 (12,9%) — in occipital, 7 (22,6%) — in cerebellum hemisphere, 2 (6,5%) — in skull bones, by 1 (3,2%) — in ponto-cerebellar angle, hypophysis, brain tunic, frontal sinus.

Results: Adenocarcinoma was diagnosed in 35 (71,4%) cases, melanoblastoma — 13 (26,6%), sarcoma — 1 (2,0%). Primary source was revealed in 31 patients: in skin — 13 (41,9%), in lungs — 6 (19,4%), in breast and kidneys — 4 (12,9%) accordingly, by 1 (3,2%) case in thymus, ovary, uterus, external sexual organs. Operation was radical in 32 (65,3%) persons, subtotal — in 14 (28,6%), partial — in 2 (4,1%), in 1 — biopsy. In early period 1 (2,0%) patient died (thromboemboly of pulmonary artery), the rest 48 were distributed into groups which underwent: in 1st group only CT — 9 (18,8%) persons; in 2nd group only RT — 6 (12,5%); in 3rd group RT and CT — 3 (6,3%); the rest 30 (62,4%) did not undergo any special treatment. In one year survived: in 3rd group — 100%, in 1st and 2nd groups — 66,7%; in persons without treatment — 33,3%.

Conclusion: In MBT combination of RT and CT is the best tactics of treatment. Further perspective is continuation of research with evaluation of patients health-related quality of life.

Author Biographies

Vladimir Pyatikop, Kharkiv National Medical University, Kharkiv

Department of Neurosurgery

Viktor Starenkiy, Grigoriev Institute for Medical Radiology, Kharkiv

Department of Distant, Combined Radiation and Complex Therapy

Mohamad Adnan Al-Trawneh, Kharkiv National Medical University, Kharkiv

Department of Neurosurgery

Yuri Kotlyarevskiy, Kharkiv Regional Clinical Hospital – Center of Emergency Medical Care and Disaster Medicine, Kharkiv

Neurosurgery Department

Igor Kutovoy, Kharkiv National Medical University, Kharkiv

Department of Neurosurgery


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How to Cite

Pyatikop, V., Starenkiy, V., Al-Trawneh, M. A., Kotlyarevskiy, Y., & Kutovoy, I. (2015). The effectiveness of the combined treatment of metastatic brain tumors. Ukrainian Neurosurgical Journal, (4), 15–21.



Original articles