Features of the course of aneurysmal subarachnoid hemorrhage and risk of the development of cerebral vasospasm: literature review


  • Valeriy Zaporozhan Odessa National Medical University, Odessa, Ukraine
  • Iuliia Solodovnikova Odessa National Medical University, Odessa, Ukraine
  • Anatoliy Son Odessa National Medical University, Odessa, Ukraine




aneurismal subarachnoid hemorrhage, vasospasm, biomarkers


Cerebral vasospasm is one of the most hazard complication of aneurysmal subarachnoid hemorrhage, that has a significant impact on mortality and may cause of poor functional recovery in patients. Detection of early clinical predictors of vasospasm and poor outcome is serious problem in modern neurosurgery and neurology. The paper presents the modern biomarkers and predictors of the course of aneurysmal subarachnoid hemorrhage and risk factors for cerebral vasospasm. Datas from studies on the most promising areas of diagnosis and treatment of vasospasm also analyzed; own data are included to the discussion.

Author Biographies

Valeriy Zaporozhan, Odessa National Medical University, Odessa


Iuliia Solodovnikova, Odessa National Medical University, Odessa

Department of Neurology

Anatoliy Son, Odessa National Medical University, Odessa

3rd Department of Surgery with the Neurosurgery Course


1. Crobeddu E, Pilloni G, Tardivo V, Fontanella MM, Panciani PP, Spena G, Fornaro R, Altieri R, Agnoletti A, Ajello M, Zenga F, Ducati A, Garbossa D. Role of nitric oxide and mechanisms involved into cerebral injury after subarachnoid hemorrhage: is nitric oxide a possible answer to cerebral vasospasm? J Neurosurg Sci. 2015 Jan 20. [Epub ahead of print]. [PubMed]

2. Cremers CH, Dankbaar JW, Vergouwen MD, Vos PC, Bennink E, Rinkel GJ, Velthuis BK, van der Schaaf IC. Different CT perfusion algorithms in the detection of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neuroradiology. 2015;57(5):469-74. [CrossRef] [PubMed]

3. Dhar R, Diringer MN. Relationship between angiographic vasospasm, cerebral blood flow, and cerebral infarction after subarachnoid hemorrhage. Acta Neurochir. 2015;120:161-5. [CrossRef] [PubMed]

4. Gollwitzer S, Groemer T, Rampp S, Hagge M, Olmes D, Huttner HB, Schwab S, Madžar D, Hopfengaertner R, Hamer HM. Early prediction of delayed cerebral ischemia in subarachnoid hemorrhage based on quantitative EEG: a prospective study in adults. Clin Neurophysiol. 2015 Aug;126(8):1514-23. [CrossRef] [PubMed]

5. Loch Macdonald R. Vasospasm: my first 25 years-what worked? what didn't? what next? Acta Neurochir. 2015;120(suppl.):1-10. [CrossRef] [PubMed]

6. Souza ML. Association of Fisher scale and changes of language in patients with aneurysmal subarachnoid hemorrhage. Arq Neuropsiquiatr. 2014 Nov;72(11):907. [CrossRef] [PubMed]

7. Pegoli M, Mandrekar J, Rabinstein AA, Lanzino G. Predictors of excellent functional outcome in aneurysmal subarachnoid hemorrhage. J Neurosurg. 2015 Feb;122(2):414-8. [CrossRef] [PubMed]

8. Stein M, Brokmeier L, Herrmann J, Scharbrodt W, Schreiber V, Bender M, Oertel MF. Mean hemoglobin concentration after acute subarachnoid hemorrhage and the relation to outcome, mortality, vasospasm, and brain infarction. J Clin Neurosci. 2015 Mar;22(3):530-4. [CrossRef] [PubMed]

9. Kanamaru K, Suzuki H, Taki W. Risk factors for vasospasm-induced cerebral infarct when both clipping and coiling are equally available. Acta Neurochir. 2015;120(suppl.):291-5. [CrossRef] [PubMed]

10. Oras J, Grivans C, Dalla K, Omerovic E, Rydenhag B, Ricksten SE, Seeman-Lodding H. High-sensitive troponin T and N-terminal pro B-type natriuretic peptide for early detection of stress-induced cardiomyopathy in patients with subarachnoid hemorrhage. Neurocrit Care. 2015;23(2):233-42. [CrossRef] [PubMed]

11. Varsos GV, Budohoski KP, Czosnyka M, Kolias AG, Nasr N, Donnelly J, Liu X, Kim DJ, Hutchinson PJ, Kirkpatrick PJ,Varsos VG, Smielewski P. Cerebral vasospasm affects arterial critical closing pressure. J Cereb Blood Flow Metab. 2015 Feb;35(2):285-91. [CrossRef] [PubMed]

12. da Costa L, Houlden D, Rubenfeld G, Tymianski M, Fisher J, Fierstra J. Impaired cerebrovascular reactivity in the early phase of subarachnoid hemorrhage in good clinical grade patients does not predict vasospasm. Acta Neurochir. 2015;120(suppl.):249-53. [CrossRef] [PubMed]

13. Faust K, Horn P, Schneider UC, Vajkoczy P. Blood pressure changes after aneurysmal subarachnoid hemorrhage and their relationship to cerebral vasospasm and clinical outcome. Clin Neurol Neurosurg. 2014 Oct;125:36-40. [CrossRef] [PubMed]

14. Budohoski KP, Czosnyka M, Kirkpatrick PJ, Reinhard M, Varsos GV, Kasprowicz M, Ząbek M, Pickard JD, Smielewski P. Bilateral failure of cerebral autoregulation is related to unfavorable outcome after subarachnoid hemorrhage. Neurocrit Care. 2014;22(1):65-73. [CrossRef] [PubMed]

15. Edvinsson L, Povlsen GK, Ahnstedt H, Waldsee R. CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediatedvasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function. J Neuroinflammation. 2014;11:207. [CrossRef] [PubMed]

16. Ramesh SS, Prasanthi A, Bhat DI, Devi BI, Cristopher R, Philip M. Correlation between plasma total nitric oxide levels and cerebral vasospasm and clinical outcome in patients with aneurysmal subarachnoid hemorrhage in Indian population. J Neurosci Rural Pract. 2014;5(1):22-7. [CrossRef] [PubMed]

17. Kiser TH. Cerebral vasospasm in critically III patients with aneurysmal subarachnoid hemorrhage: does the evidence support the ever-growing list of potential pharmacotherapy interventions? Hosp Pharm J. 2014 Nov;49(10):923-41. [CrossRef] [PubMed]

18. Rabinstein AA, Lanzino G, Wijdicks EF. Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage. Lancet Neurol. 2010;9(5):504-519. [CrossRef] [PubMed]

19. Toyoda T, Yonekura I, Iijima A, Shinozaki M, Tanishima T. Clot-clearance rate in the sylvian cistern is associated with the severity of cerebral vasospasm after subarachnoid hemorrhage. Acta Neurochir. 2015;120:275-7. [CrossRef] [PubMed]

20. Merino C, Heap P, Vergara V, Yáñez A, Rivera R. Changes in cerebral blood flow velocity in supine and sitting position in patients with aneurysmal subarachnoid hemorrhage. Rev Med Chil. 2014 Dec;142(12):1502-9. [CrossRef] [PubMed]

21. Riordan MA, Kyle M, Dedeo C, Villwock MR, Bauer M, Vallano ML, Deshaies EM. Mild exercise reduces cerebral vasospasm after aneurysm subarachnoid hemorrhage: a retrospective clinical study and correlation with laboratory investigation. Acta Neurochir. 2015;120(suppl.):55-61. [CrossRef] [PubMed]



How to Cite

Zaporozhan, V., Solodovnikova, I., & Son, A. (2015). Features of the course of aneurysmal subarachnoid hemorrhage and risk of the development of cerebral vasospasm: literature review. Ukrainian Neurosurgical Journal, (4), 9–14. https://doi.org/10.25305/unj.55943



Review articles