Presence of оnсо- and herpes viruses in medulloblastomas and gliomas (review of the literature and our own observations)
DOI:
https://doi.org/10.25305/unj.55646Keywords:
medulloblastoma, glioma, polyomavirus, cytomegalovirus, herpesvirus VII typeAbstract
Introduction. Today the role of viral contamination of brain tumors and possibility of antiviral therapy are studied widely.
Materials and methods. Polymerase chain reaction was used to study the presence of оnсо- and herpes viruses in medulloblastomas and gliomas of the brain.
Results. At research of 61 tumor samples contamination by different viruses was revealed in 47.5% cases, most often — in medulloblastomas (in 51%), less often — in glioblastomas (in 22%). More often virus of herpes VII type (in 16.3%) and polyomaviruses (in 10 %) were found. The shortest period before disease recurrence was observed in patients with medulloblastoma at contamination by polyomavirus SV-40.
Conclusions. The role of viruses in oncogenesis initiation, their prognostic value and possibilities to use antiviral therapy for brain tumors treatment need further research.
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Copyright (c) 2012 Oleksandr Lisianyi, A. Potapova, Viktor Gudkov, Petro Onishchenko, Volodymyr Fedirko, Dmytro Tsyurupa
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