The еffectiveness of simvastatin in treating vasospasm in patients with rupture of arterial cerebral aneurysms


  • Svitlana Dudukina Neuroreanimation Department, Mechnikov Dnepropetrovsk Regional Clinical Hospital, Dnepropetrovsk, Ukraine



arterial vasospasm, simvastatin


Introduction. Vasospasm is a leading cause of disability and mortality in cases of arterial cerebral aneurysms rupture. The search for new methods of prevention and treatment still continues.

Materials and methods. The study of the effectiveness of simvastatin in the prevention and treatment of vasospasm has been carried out. Spasm severity was assessed by transcranial Doppler, the level of C-reactive protein.

Results. Decrease in the severity of arterial spasm and shortening of its regression term with simvastatin has been noted.

Conclusions. The use of simvastatin in acute aneurysmal subarachnoid hemorrhage origin modifies the course of vasospasm, helps to prevent the development of critical vasospasm, reduces the activity of endothelial inflammation, reduces the duration of hospital stay.


1. Atroshchenko Ye.S. Pleyotropnyye effekty statinov: novyy aspekt deystviya ingibitorov GMG-KoA-reduktazy. Meditsinskiye novosti. 2004;3:59—66. Russian.

2. Bederson J, Connolly E, Batjer H et al. Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. Stroke. 2009;40(3):994-1025. [CrossRef]

3. Dhar R, Diringer M. Statins and Anti-Inflammatory Therapies for Subarachnoid Hemorrhage.Curr Treat Options Neurol. 2012;14(2):164-174. [CrossRef] [PubMed]

4. Wong G, Poon W. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals. 2010;3(10):3186-3199. [CrossRef]

5. Gaydar B V, Semenyutin VB, Parfenov VE, Svistov D V. Transkranialnaya dopplerografiya v neyrokhirurgii. [Transcranial Doppler in Neurosurgery]. St. Petersburg:Elbi; 2008. Russian.

6. Fountas K, Tasiou A, Kapsalaki E et al. Serum and cerebrospinal fluid C-reactive protein levels as predictors of vasospasm in aneurysmal subarachnoid hemorrhage. Neurosurgical FOCUS. 2009;26(5):E22. [CrossRef] [PubMed]



How to Cite

Dudukina, S. (2013). The еffectiveness of simvastatin in treating vasospasm in patients with rupture of arterial cerebral aneurysms. Ukrainian Neurosurgical Journal, (1), 45–49.



Original articles