Secondary changes in spinal cord due to prolonged compression at trauma of cervical spine
Keywords:spinal trauma, secondary trauma, oedema, ischemia, neuroinflammation, excitotoxicity, apoptosis
Introduction. One of the reasons for secondary changes in spinal cord at spinal trauma — is it’s tissue alteration by vertebrae bone fragments and dura mater. Study of morphogenesis in tissues of damaged spinal cord in different periods of trauma let us to estimate severity of secondary alterations and influence of early decompression.
Materials and methods. Comparative morphological study of macro- and micropreparations in 4 patients, died because of cervical spine contusion on the 4, 8, 10th and 71st day was provided.
Results. Secondary alterations in spinal cord at prolonged compression were revealed. Secondary trauma is less expressed after early decompression performing.Conclusions. 1. The initial trauma of the spinal cord at prolonged compression is accompanied by progressive secondary changes of it’s tissue — ischemia, oedema, inflammation, and as a consequence by irreversible changes of spinal cord structure and function. 2. Early surgery may prevent secondary alteration spreading and is promising in treatment of such patients.
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