Experimental study of safety of levofloxacin intrathecal application

Authors

  • Sergiy Borshchov Gromashevsky Institute of Epidemiology and Infectious Diseases, Kiev, Ukraine
  • Igor Filchakov Gromashevsky Institute of Epidemiology and Infectious Diseases, Kiev, Ukraine
  • Petro Sinitsyn Komisarenko Institute of Endocrinology and Metabolism, Kiev, Ukraine
  • Natalia Seredinskaya Institute of Pharmacology and Toxicology, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.54151

Keywords:

levofloxacin, intrathecal application, safety, toxicity

Abstract

Purpose: to set safety of levofloxacin intrathecal application in experiment on rats.

Materials and methods. In the experiment purebred white male rats were used in which clinical observation, general clinical and biochemical blood tests and electrocardiogram were done.

Results. There was the significant physiological weight gain of animals in main and control groups which is proof of the lack of negative effect of levofloxacin intrathecal application.

Studying the effect of levofloxacin intrathecal application on autonomic and behavioral functions in rats in first 2 h established short-term (up to 5 min) irritant. Studying hematological and biochemical parameters of blood of control and experimental animals no significant differences were revealed.

Conclusions. Levofloxacin intrathecal application in a doze 0.1875 mg/kg in combination with dexamethasone in a dose 0.05 mg / kg is safe.

Author Biographies

Sergiy Borshchov, Gromashevsky Institute of Epidemiology and Infectious Diseases, Kiev

Department of Intensive Care and Detoxycation

Igor Filchakov, Gromashevsky Institute of Epidemiology and Infectious Diseases, Kiev

Laboratory of Intestinal Infections and Parasitic Diseases

Petro Sinitsyn, Komisarenko Institute of Endocrinology and Metabolism, Kiev

Department of Endocrinology, Reproduction and Adaptation

Natalia Seredinskaya, Institute of Pharmacology and Toxicology, Kiev

Department of Cardiovascular Agents Pharmacology

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Published

2013-09-27

How to Cite

Borshchov, S., Filchakov, I., Sinitsyn, P., & Seredinskaya, N. (2013). Experimental study of safety of levofloxacin intrathecal application. Ukrainian Neurosurgical Journal, (3), 61–64. https://doi.org/10.25305/unj.54151

Issue

No. 3 (2013)

Section

Original articles

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Copyright (c) 2013 Sergiy Borshchov, Igor Filchakov, Petro Sinitsyn, Natalia Seredinskaya

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