Titer of antibodies to cytomegalovirus in blood of patients at brain tumors
Keywords:cytomegalovirus (CMV), antibody, brain tumors, herpes simplex virus (HSV)
The role of cytomegalovirus (CMV), induction and stimulation of malignant tumors growth of different localization, including brain tumors, is intensively studied in the recent years. Data about this virus importance in brain tumors formation are contradictory. The aim of the research was to study titers of antibodies to CMV and herpes simplex virus (HSV) in the blood of neurooncological patients and presence of virus in brain tumors.
Materials and methods. Blood serum was studied in 66 patients with different brain tumors, in 50 — with chronic inflammatory diseases of the nervous system (first control group), in 50 — with chronic gynecopathies (second control group), and also 42 cytologic imprint of tumors, been removed at operation, were studied. Antibodies to the viruses were determined using accepted methods of enzyme immunoassay, the virus in imprints was determined using kits «CMV monoskan».
Results. It was found that antibodies to HSV were determined frequently at neurological diseases and gynecopathology than at neurooncology. Antibodies to CMV, unlike HSV, were determined more frequently at neurooncology, theit titer was 2–4 times higher than at other diseases. In the cells of malignant brain gliomas (glioblastomas, medulloblastomas) CMV antigens were determined frequently than in bening tumors that indicated high tropism of CMV to malignant tumors and perhaps it’s stimulating influence on the oncogenesis.Conclusions. CMV-infection more frequently than HSV accompanies brain tumors growth.
1. Harkins L, Matlaf L, Soroceanu L Klemm K, Britt WJ, Wang W, Bland KI, Cobbs CS. Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae. 2010;1(1):8-16. [CrossRef] [PubMed]
3. Melnick M, Sedghizadeh P, Allen C, Jaskoll T. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012;92(1):118-25. [CrossRef] [PubMed]
4. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, King PH, Nabors LB, Cobbs CG, Britt WJ. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. 2002 Jun 15;62(12):3347-50. [PubMed]
7. Shen Y, Zhu H, Shenk T. Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins. Proc Natl Acad Sci. USA. 1997;94(7):3341-5. [CrossRef] [PubMed]
8. Cinatl J, Vogel J, Kotchetkov R, Wilhelm Doerr H. Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression. FEMS Microbiol Rev. 2004;28(1):59-77. [CrossRef] [PubMed]
11. Ranganathan P, Clark P, Kuo J, Salamat M, Kalejta R. Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples. J Virol. 2011;86(2):854-64. [CrossRef]
12. Rahbar A, Stragliotto G, Orrego A, Peredo I, Taher C, Willems J, Söderberg-Naucler C. Low levels of human cytomegalovirus infection in glioblastoma multiforme associates with patient survival; -a case-control study. Herpesviridae. 2012 Mar 16;3:3. [CrossRef] [PubMed]
13. Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, Darabi A, Khan Z, Sveinbjörnsson B, FuskevÅg OM, Segerström L, Nordenskjöld M, Siesjö P, Kogner P, Johnsen JI, Söderberg-Nauclér C. Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest. 2011;121(10):4043-55. [CrossRef] [PubMed]
14. Lisyanyy AN, Malysheva TA, Stanetskaya DN. Immunofluorestsentnoye opredeleniye TSMV antigenov v opukholyakh golovnogo mozga [Immunofluorescence determination of CMV antigens in brain tumors]. Ímunologíya ta alergologíya. Teoríya ta praktika. 2012;2:39. Russian.
15. Kachkov IA, Biktimirov RG, Zakharov AV, Chumakov VA, Suchkov SV. Glial'nyye opukholi golovnogo mozga:klassifikatsiya, immunopatogenez i immuno genodiagnostika [Glial brain tumors: classification, Immunopathogenesis and immuno gene diagnostics]. Vestn. RAMN. 2005;6:36-42. Russian.
How to Cite
Copyright (c) 2013 Nikolay Lisianyi, Tatyana Malyshevа, Oleksandr Lisianyi, Antonina Klyuchnikova, Larisa Kot, Diana Stanetskaya, D. Besruchko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.