Titer of antibodies to cytomegalovirus in blood of patients at brain tumors


  • Nikolay Lisianyi Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Tatyana Malysheva Department of Neuropathomorphology, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Oleksandr Lisianyi Romodanov Neurosurgery Institute, Kiev, Ukraine https://orcid.org/0000-0002-9965-9993
  • Antonina Klyuchnikova Department of Neuroimmunology, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Larisa Kot Clinical Laboratory, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Diana Stanetskaya Department of Neuroimmunology, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • D. Besruchko Romodanov Neurosurgery Institute, Kiev, Ukraine




cytomegalovirus (CMV), antibody, brain tumors, herpes simplex virus (HSV)


The role of cytomegalovirus (CMV), induction and stimulation of malignant tumors growth of different localization, including brain tumors, is intensively studied in the recent years. Data about this virus importance in brain tumors formation are contradictory. The aim of the research was to study titers of antibodies to CMV and herpes simplex virus (HSV) in the blood of neurooncological patients and presence of virus in brain tumors.

Materials and methods. Blood serum was studied in 66 patients with different brain tumors, in 50 — with chronic inflammatory diseases of the nervous system (first control group), in 50 — with chronic gynecopathies (second control group), and also 42 cytologic imprint of tumors, been removed at operation, were studied. Antibodies to the viruses were determined using accepted methods of enzyme immunoassay, the virus in imprints was determined using kits «CMV monoskan».

Results. It was found that antibodies to HSV were determined frequently at neurological diseases and gynecopathology than at neurooncology. Antibodies to CMV, unlike HSV, were determined more frequently at neurooncology, theit titer was 2–4 times higher than at other diseases. In the cells of malignant brain gliomas (glioblastomas, medulloblastomas) CMV antigens were determined frequently than in bening tumors that indicated high tropism of CMV to malignant tumors and perhaps it’s stimulating influence on the oncogenesis.

Conclusions. CMV-infection more frequently than HSV accompanies brain tumors growth.

Author Biographies

Nikolay Lisianyi, Romodanov Neurosurgery Institute, Kiev

Department of Neuroimmunology

Oleksandr Lisianyi, Romodanov Neurosurgery Institute, Kiev

Department of Infratentorial Neuro-Oncology,

D. Besruchko, Romodanov Neurosurgery Institute, Kiev

Department of Neuropathomorphology


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How to Cite

Lisianyi, N., Malysheva, T., Lisianyi, O., Klyuchnikova, A., Kot, L., Stanetskaya, D., & Besruchko, D. (2013). Titer of antibodies to cytomegalovirus in blood of patients at brain tumors. Ukrainian Neurosurgical Journal, (3), 34–38. https://doi.org/10.25305/unj.54146



Original articles