Low-dose linac-based stereotactic radiosurgery for skull base meningiomas
Keywords:skull base meningiomas, stereotactic radiosurgery, linear accelerator
Objective. To analyze the results of patients’ treatment skull base meningiomas, using linac-based low-dose (≤12.5 Gy) SRS, to estimate the efficacy of this method.
Materials and methods. SRS, using linear accelerator «Trilogy + BrainLab» was performed in 75 patients with skull base meningiomas (Karnofsky index ≥ 80). The target’s volume ranged from 1.21 до 20.9 см3, the marginal dose — from 11 to 12.5 Gy, the part of target that received the marginal dose, ranged from 70% to 100%. 61 patients were followed from 2 to 44 months (median, 11 months).
Results. The clinical status was unchanged in 96.7% of patients. After SRS, 47.6% patients presented with tumor size reduction; 50.8 % remained stable; in 98.4% — the control of tumor growth was achieved.
Conclusions. SRS − is effective method of treatment for skull base meningiomas, providing high rate of tumor control (98.4%) and ensuring safety of patient’s neurological status (Karnofsky index ≥ 80). SRS with using lower marginal doses (≤12.5 Gy), allows to reduce frequency and severity of both transient and permanent neuropathy (in 96.7% cases).
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Copyright (c) 2015 Irina Kruchok, Olga Chuvashova, Lyudmila Verbova, Andrey Gryazov
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