Cerebellar medulloblastomas in children (age-related aspect)
Keywords:medulloblastomas, surgical treatment, results, children
Introduction. Cerebellar medulloblastomas are high-malignant embryonic brain tumours, which are diagnosed mainly in children and characterized by early dissemination of tumors. According to the data of literature there are some features of course and results of treatment of medulloblastomas depending on age of child.
Materials and methods. The analysis of 653 supervisions of cerebellar medulloblastoma is conducted. The peaks of formation of tumours are educed in 4 years old (84 supervisions) and 7 years old (74 supervisions). All patients were operated, the diagnosis of medulloblastoma was verified histologically.
Results. A total resection of tumour was executed at 36.8% of patients, subtotal — at 52%, partial — at 11.2%. At 166 (25.4%) patients resection of tumours was complemented by the shunt operations. During 30 days after resection 49 (7.5%) patients died. A catamnesis was estimated in 488 (74.7%) children in terms from one month to 10 years. Median of survivability was 18 months. Two-year survivability is established in 42.0%, five-year in 6.0%.
Conclusions. Medulloblastomas formed 18.2% of all brain tumours in children, in the structure of embryonic tumours — 92.6%. For the children of the early age the total resection of tumours was possible in 40.3% cases, subtotal — in 42.0%. Frequency of early dissemination of tumors in the different age-related groups of children statistically does not differ with small predominance in the children of early age. Influence of volume of combined therapy requires a study in the different age-related groups of children on survivability in postoperative period.
1. Louis D, Ohgaki H, Wiestler O, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neuropathol. 2007;114(2):97-109. [CrossRef] [PubMed]
2. Matsko DE. Atlas opukholey tsentral'noy nervnoy sistemy [Atlas of tumors of the central nervous system]. St. Petersburg: RNSI; 1998. Russian.
3. Johnston D, Daniel L, Keene L, Steinbok P, Sung L, Carret AS, Crooks B, Strother D, Wilson B, Odame I, Eisenstat DD, Mpofu C, Zelcer S, Huang A, Bouffet E. Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report. J. Neurooncol. 2007;86(1):101–108. [CrossRef] [PubMed]
4. N. Gerber, K. von Hoff, W. Treulieb Hyperfractionated craniospinal radiochemotherapy followed by maintenance chemotherapy in children older than 4 years with supratentorial primitive neuroectodermal tumor (STPNET). In: SIOP Abstract Book, 40th Congress of the SIOP;2008 Oct. 2-6; Berlin, 2008. p.46.
5. Kumirova EV. Embrional'nyye opukholi tsentral'noy nervnoy sistemy u detey: optimizatsiya lecheniya i rezul'taty [Embryonic tumors of the central nervous system in children: optimization of treatment and results] [dissertation]. Moskva [Russia]: Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology; 2010. Russian.
6. Orlov YuA, Shaversky AV. Medulloblastomy mozzhechka u detey: rezul'taty lecheniya i prognosticheskiye factory [Cerebellar medulloblastoma in children: outcome and prognostic factors]. In: Abstract Book of IV Congress of Neurosurgeons of Ukraine; 2008 May 27-30; Dnepropetrovsk, Ukraine. Dnepropetrovsk, 2008. p.135. Russian.
7. Shaversky AV. Pukhlyny holovnoho mozku u ditey molodshoho viku [Brain tumors in young children] [dissertation]. Kiev (Ukraine): Romodanov Neurosurgery Institute; 2014. Ukrainian.
8. Chan MY, Teo WY, Seow WT, Tan AM. Epidemiology management and treatment outcome of medulloblastoma Singapore. Ann. Acad. Med. Singapore. 2007;36(5):314-318. [PubMed]
9. Rutkowski S. Chemotherapeutic strategies for young children with brain tumors. In: SIOP Abstract Book, 40th Congress of the SIOP; 2008 Oct. 2-6; Berlin — Berlin, 2008. p.7.
11. Shaversky AV, Orlov YuA, Mikhaylyuk VS. Dyahnostyka y lechenye medulloblastom mozzhechka u detey [Diagnosis and Treatment of Cerebellar Medulloblastoma in Children]. Collection of Scientific Works of Staff Members of P.L. Shupyk NMAPE . 2013;22(3):34-41. Ukrainian.
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