Cerebellar medulloblastomas in children (age-related aspect)
DOI:
https://doi.org/10.25305/unj.50118Keywords:
medulloblastomas, surgical treatment, results, childrenAbstract
Introduction. Cerebellar medulloblastomas are high-malignant embryonic brain tumours, which are diagnosed mainly in children and characterized by early dissemination of tumors. According to the data of literature there are some features of course and results of treatment of medulloblastomas depending on age of child.
Materials and methods. The analysis of 653 supervisions of cerebellar medulloblastoma is conducted. The peaks of formation of tumours are educed in 4 years old (84 supervisions) and 7 years old (74 supervisions). All patients were operated, the diagnosis of medulloblastoma was verified histologically.
Results. A total resection of tumour was executed at 36.8% of patients, subtotal — at 52%, partial — at 11.2%. At 166 (25.4%) patients resection of tumours was complemented by the shunt operations. During 30 days after resection 49 (7.5%) patients died. A catamnesis was estimated in 488 (74.7%) children in terms from one month to 10 years. Median of survivability was 18 months. Two-year survivability is established in 42.0%, five-year in 6.0%.
Conclusions. Medulloblastomas formed 18.2% of all brain tumours in children, in the structure of embryonic tumours — 92.6%. For the children of the early age the total resection of tumours was possible in 40.3% cases, subtotal — in 42.0%. Frequency of early dissemination of tumors in the different age-related groups of children statistically does not differ with small predominance in the children of early age. Influence of volume of combined therapy requires a study in the different age-related groups of children on survivability in postoperative period.
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