The frequency of detection of DNA of Herpesvirus 4 types in brain tumours
Keywords:brain tumours, gliomas, human herpesvirus type 4
Objective. To study the frequency of identifying DNA of human herpesvirus type 4 (Epstein-Barr virus – EBV) in different brain tumours.
Materials and methods. Following the surgical resection, 89 samples of brain tumours were analyzed by real time PCR (“DNA technology” commercial kit) for the presence of EBV DNA.
Results. EBV DNA was detected in about 40% of the samples of different brain tumours. The frequency of EBV DNA in the samples of extracerebral tumours was higher than in intracerebral glial tumours. EBV DNA positivity in benign gliomas was superior to that in malignant ones. The mechanisms of EBV infection of tumour cells in the brain and the role of EBV in stimulation of tumour growth have not been yet elucidated.
Conclusion. EBV DNA is detected in the cells of brain tumours of different histology, prevalently in glial tumours.
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Copyright (c) 2015 Nikolay Lisianyi, Antonina Klyuchnikova, Oleksandr Lisianyi, Lyudmila Belska, Tatyana Malysheva
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