Modern approaches to vestibular schwannomas treatment in patients with neurofibromatosis type 2 using stereotactic radiosurgery


  • Oksana Zemskova Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Olga Chuvashova Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine



vestibular schwannoma, neurofibromatosis type 2, stereotactic radiosurgery


Introduction. The results and efficacy of stereotactic radiosurgery (SRS) in treatment of patients with vestibular shwannomas (VS) associated with neurofibromatosis type 2 (NF2) are analyzed.

Materials and methods. In 12 patients with NF2 (in total 17 VS) 15 VS-NF2 were irradiated using linear accelerator Trilogy. The prescribed doze (PD) for VS-NF2 was 12.0 – 13.0 Gy (median 12.5 Gy, in average 12.5 Gy); maximal doze — from 13.01 to 15.0 Gy (median 14.31 Gy, in average 14.19 Gy); targets volume — from 0.226 to 8.258 cm3 (median 3.564 cm3, in average 3.61 cm3).

Results. In 15 VS-NF2, treated with SRS, local control was achieved in 93%. In 7 patients after SRS there were no negative changes in neurological state, in 4 of them positive clinical dynamics was observed. Hearing preservation rate was 57%. After SRS occlusive hydrocephalus, resistant trigeminal pain, aggravation of facial nerve dysfunction were not identified.

Conclusions. SRS is non-invasive method of VS-NF2 treatment, it provides local control and preservation of cranial nerves function adjacent to the tumor.


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How to Cite

Zemskova, O., & Chuvashova, O. (2014). Modern approaches to vestibular schwannomas treatment in patients with neurofibromatosis type 2 using stereotactic radiosurgery. Ukrainian Neurosurgical Journal, (3), 66–71.



Original articles