Effectiveness of surgical and combined treatment of supratentorial primitive neuroectodermal tumors in children


  • Yuriy Orlov Department of Pediatric Neurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Andrii Shaverskyi Department of Pediatric Neurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine https://orcid.org/0000-0002-3776-5563
  • Vadym Ziabchenko Department of Pediatric Neurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Tatyana Malysheva Neuropathomorphology Department, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Оksana Chernenko Department of Neuropathomorphology, Romodanov Neurosurgery Institute, Kiev, Ukraine




brain tumors, primitive supratentorial neuroectodermal tumors, chemiotherapy, surgery, younger children


Introduction. The results of use of modern methods of treatment of malignant embryonic brain tumors — supratentorial primitive neuroectodermal tumors (sPNET) are given.

Materials and methods. The retrospective analysis of treatment results of 73 children with primitive brain sPNET in a period 1995–2011 was done. Combined methods of treatment were used — surgery, radiotherapy and chemotherapy.

Results. The study results demonstrate the need for aggressive therapy at such malignant tumors. After surgery death rate was 5.5%, survival rate in average — 31.2 months. Surgery radicalism, application of radiotherapy and chemotherapy affect the survival rate and quality of life of the patient.

Conclusion. Patients older than 3 years at whom according to treatment protocols at sPNEO radiotherapy can be used, as well as a comprehensive approach to treatment are positive predictors of survival and quality of life.


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How to Cite

Orlov, Y., Shaverskyi, A., Ziabchenko, V., Malysheva, T., & Chernenko О. (2014). Effectiveness of surgical and combined treatment of supratentorial primitive neuroectodermal tumors in children. Ukrainian Neurosurgical Journal, (3), 19–23. https://doi.org/10.25305/unj.47486



Original articles