Pathomorphological and immunohistochemical characteristics of vascularisation in benign and malignant meningiomas of the brain
Keywords:meningioma, angiogenesis, vascular endothelial growth factor, vascular endothelial growth factor receptor-1
Aim. To determine the expression level of angiogenesis markers VEGF and VEGFR-1 in different histological subtypes of benign and in anaplastic meningiomas.
Materials and methods. 32 cases of meningiomas which were removed during neurosurgical operations were analyzed. We studied peculiarities of the expression of angiogenesis markers in benign and malignant brain meningiomas.
Results. VEGF expression was observed in tumor cells as well as in endothelial cells in 38, 8% of all cases. Tumors with weak, focal expression and also with immunonegative areas comprised 22, 2% of investigated cases. Expression of VEGFR-1 in microvessel endothelial cells was present in 61, 1% of analysed cases.
Conclusions.: 1. The expression level of VEGF significantly differs among various subtypes of benign meningiomas with the most intensive expression in transitional subtypes.
2. Fibroblastic subtypes of benign meningiomas are characterized by the least expression level of VEGF and VEGFR-1.
3. The relationship between the grade of meningiomas according to the WHO classification (2007) and the expression level of VEGF was not determined. Thus, the angiogenic potential depends upon the histological structure and does not depend on the degree of malignancy.
4. The expression level of VEGFR-1 doesn’t significantly differ between benign and anaplastic meningiomas.
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