Cisplacel drug in combined and complex treatment of patients with high-grade (III–IV) brain gliomas
DOI:
https://doi.org/10.25305/unj.45299Keywords:
high-grade (III–IV) brain gliomas, surgical treatment, local intraoperative chemotherapy, CisplacelAbstract
Purpose. To estimate efficacy of intraoperative local chemotherapy with drug Cisplcel in the combined and complex treatment of patients with high-grade (III–IV) brain gliomas.
Materials and methods. 114 patients were included in the study, combined or complex treatment was conducted; in 57 patients at surgery performing in the bed of the tumor after it’s removal Cisplacel — a drug for intraoperative chemotherapy was implanted; in 57 — local chemotherapy was not used.
Results. In patients aged 50 years and younger after radical or subtotal removal of high-grade brain glioma Cisplacel application significantly increased the median survival from 14 to 21 months; 1-, 3- and 5-year survival rates — respectively from (67.6±10.1), (12.1±7.9) and (12,1±7.9)% to (90.9±6.1), (25.3±10,9) and (16.8±10,0)% (p=0.048). In patients older than 50 years, significant differences in survival rates were not identified.
Conclusions. 1. Cisplacel including in the scheme of combined and complex treatment of patients aged 50 years and younger with high-grade brain glioma after it’s radical or subtotal removal significantly increased the median survival and 1-, 3- and 5-year survival rates (p=0.048).
2. Justification of indications for Cisplacel use in other patients needs further study and careful analysis and estimation of prognostic factors affecting treatment outcomes.
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Copyright (c) 2015 Valeriy Sinajkо, Yuriy Shanko, Evgeniy Korotkevich, Pavel Bychkovsky, Tatyana Yurkshtovich, Yuriy Grachev, Nataliya Artemova
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