Cisplacel drug in combined and complex treatment of patients with high-grade (III–IV) brain gliomas

Authors

  • Valeriy Sinajkо N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
  • Yuriy Shanko Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus
  • Evgeniy Korotkevich Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus
  • Pavel Bychkovsky Research Institute of Physicochemical Problems, Belarusian State University, Minsk; Unitechprom BSU National Unitary Concern, Minsk, Belarus
  • Tatyana Yurkshtovich Research Institute of Physicochemical Problems, Belarusian State University, Minsk, Belarus
  • Yuriy Grachev N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
  • Nataliya Artemova N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus

DOI:

https://doi.org/10.25305/unj.45299

Keywords:

high-grade (III–IV) brain gliomas, surgical treatment, local intraoperative chemotherapy, Cisplacel

Abstract

Purpose. To estimate efficacy of intraoperative local chemotherapy with drug Cisplcel in the combined and complex treatment of patients with high-grade (III–IV) brain gliomas.

Materials and methods. 114 patients were included in the study, combined or complex treatment was conducted; in 57 patients at surgery performing in the bed of the tumor after it’s removal Cisplacel — a drug for intraoperative chemotherapy was implanted; in 57 — local chemotherapy was not used.

Results. In patients aged 50 years and younger after radical or subtotal removal of high-grade brain glioma Cisplacel application significantly increased the median survival from 14 to 21 months; 1-, 3- and 5-year survival rates — respectively from (67.6±10.1), (12.1±7.9) and (12,1±7.9)% to (90.9±6.1), (25.3±10,9) and (16.8±10,0)% (p=0.048). In patients older than 50 years, significant differences in survival rates were not identified.

Conclusions. 1. Cisplacel including in the scheme of combined and complex treatment of patients aged 50 years and younger with high-grade brain glioma after it’s radical or subtotal removal significantly increased the median survival and 1-, 3- and 5-year survival rates (p=0.048).

2. Justification of indications for Cisplacel use in other patients needs further study and careful analysis and estimation of prognostic factors affecting treatment outcomes.

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Published

2015-06-27

How to Cite

Sinajkо V., Shanko, Y., Korotkevich, E., Bychkovsky, P., Yurkshtovich, T., Grachev, Y., & Artemova, N. (2015). Cisplacel drug in combined and complex treatment of patients with high-grade (III–IV) brain gliomas. Ukrainian Neurosurgical Journal, (2), 59–63. https://doi.org/10.25305/unj.45299

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Section

Original articles