Epidemiology of tumors of the spinal cord and spine in Ukraine in 2000-2019
DOI:
https://doi.org/10.25305/unj.217283Keywords:
tumors of the spinal cord and spine, extramedullary tumors, intramedullary tumors, vertebral tumorsAbstract
Objective. To determine the dynamics and state of neurosurgical care for tumors of the spinal cord and spine (TSCS) in Ukraine.
Materials and methods. The work is based on the analysis of hospitalizations and surgical treatment of patients with TSCS in neurosurgical departments of Ukraine in 2000-2019.
Results. In 2019, 1,325 patients with TSCS were hospitalized in neurosurgical departments of Ukraine, which is 2,3 times more than in 2000 (567), per 1 million population - almost 3 times (34,7 vs. 11, 6 ). Over 20 years, the number of operated patients increased 2,8 times (from 385 to 1079), per 1 million population - 3,6 times (from 7,9 to 28,3), there was an increase in surgical activity by 20% (from 67,9 to 81,4%), a decrease in the general and postoperative mortality - twice (from 2,6 to 1,2% and from 2,6 to 1,3% respectively).
Patients with TSCS account for 1,5% of all patients hospitalized in neurosurgical departments of Ukraine, 12,8% of all CNS neoplasms and 5,2% of all spinal pathology. Vertebral tumors account for 42,64% of all TSCS and extramedullary tumors have an incidence rate similar to vertebral tumors (42,64%), intramedullary tumors account for 14,72%.
In 2019, 74.4% more patients with extramedullary tumors were hospitalized than in 2000 (565 and 324 respectively), and 84.5% more were operated on (463 and 251 respectively). The rate of increase is even higher per 1 million population. In 2019, there were 14.8 hospitalizations per 1 million population for extramedullary tumors, which is 2.2 times greater than in 2000 (6,6 hospitalizations), and 12,1 operations, which is 2,4 times greater than in 2000 (5,1 operations).
In 2019, patients with intramedullary tumors were hospitalized 2,2 times more than in 2000. (195 and 89 respectively), were operated 2,5 times more (151 and 61 respectively). The rate of increase is even 4higher per 1 million population. In 2019, there were 5,1 hospitalizations for intramedullary tumors per 1 million population, which is 2,8 times greater than in 2000 (1,8 hospitalizations), and 4,0 operations, which is 3,2 times greater than in 2000 (1,2 operations).
In 2019, patients with vertebral tumors were hospitalized 3.7 times more than in 2000 (565 and 154 respectively), were operated 6,4 times more (465 and 73 respectively). The rate of increase is even higher per 1 million population. In 2019, there were 14,8 hospitalizations per 1 million population for vertebral tumors, which is 4,7 greater than in 2000 (3,1 hospitalizations), and 12,2 surgeries, which is 8,2 greater than in 2000 (1,5 operations).
Сonclusions. The introduction of modern neuroimaging methods and advanced treatment methods into clinical practice has contributed to an increase in the number of hospitalizations and surgical interventions in TSCS.
References
1. Newton HB. Overview of spinal cord tumor epidemiology. In: Newton HB. Handbook of Neuro-Oncology Neuroimaging. Academic Press; 2016. p. 35-39. [CrossRef]
2. Çağlar YŞ, Doğan İ. Epidemiology of Spinal Cord Tumors. In: Arnautović KI, Gokaslan ZL, editors. Spinal Cord Tumors. Springer; 2019. p. 31-42. [CrossRef]
3. Schellinger KA, Propp JM, Villano JL, McCarthy BJ. Descriptive epidemiology of primary spinal cord tumors. J Neurooncol. 2008 Apr;87(2):173-9. [CrossRef] [PubMed]
4. Wewel JT, O’Toole JE. Epidemiology of spinal cord and column tumors. Neurooncol Pract. 2020 Nov 18;7(Suppl 1):i5-i9. [CrossRef] [PubMed] [PubMed Central]
5. Newton HB. Handbook of Neuro-Oncology Neuroimaging. Elsevier; 2016. [CrossRef]
6. Bhat AR, Kirmani AR, Wani MA, Bhat MH. Incidence, histopathology, and surgical outcome of tumors of spinal cord, nerve roots, meninges, and vertebral column - Data based on single institutional (Sher-i-Kashmir Institute of Medical Sciences) experience. J Neurosci Rural Pract. 2016 Jul-Sep;7(3):381-91. [CrossRef] [PubMed] [PubMed Central]
7. Slynhko EI, Zolotoverch AM, Nikiforova AN. [Frequency of spinal cord and spine tumors from data of neurosurgical clinics of Ukraine]. Ukrainian Neurosurgical Journal. 2007;(4):12-6. Russian. [CrossRef]
8. Dickman CA, Fehlings M, Gokaslan ZL, editors. Spinal cord and spinal column tumors: principles and practice. Thieme; 2006.
9. el-Mahdy W, Kane PJ, Powell MP, Crockard HA. Spinal intradural tumours: Part I--Extramedullary. Br J Neurosurg. 1999 Dec;13(6):550-7. [CrossRef] [PubMed]
10. Arnautovic K, Arnautovic A. Extramedullary intradural spinal tumors: a review of modern diagnostic and treatment options and a report of a series. Bosn J Basic Med Sci. 2009 Oct;9 Suppl 1:40-5. [CrossRef] [PubMed]
11. Jung KW, Park KH, Ha J, Lee SH, Won YJ, Yoo H. Incidence of primary spinal cord, spinal meninges, and cauda equina tumors in Korea, 2006-2010. Cancer Res Treat. 2015 Apr;47(2):166-72. [CrossRef] [PubMed] [PubMed Central]
12. Duong LM, McCarthy BJ, McLendon RE, Dolecek TA, Kruchko C, Douglas LL, Ajani UA. Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007. Cancer. 2012 Sep 1;118(17):4220-7. [CrossRef] [PubMed] [PubMed Central]
13. Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB. Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine. 2010 Jul;13(1):67-77. [CrossRef] [PubMed]
14. Elia-Pasquet S, Provost D, Jaffré A, Loiseau H, Vital A, Kantor G, Maire JP, Dautheribes M, Darrouzet V, Dartigues JF, Brochard P, Baldi I; Work Group. Incidence of central nervous system tumors in Gironde, France. Neuroepidemiology. 2004 May-Jun;23(3):110-7. [CrossRef] [PubMed]
15. Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A. Intradural spinal tumors in adults-update on management and outcome. Neurosurg Rev. 2019 Jun;42(2):371-388. [CrossRef] [PubMed]
16. Klekamp J. Spinal ependymomas. Part 2: Ependymomas of the filum terminale. Neurosurg Focus. 2015 Aug;39(2):E7. [CrossRef] [PubMed]
17. Chamberlain MC, Tredway TL. Adult primary intradural spinal cord tumors: a review. Curr Neurol Neurosci Rep. 2011 Jun;11(3):320-8. [CrossRef] [PubMed]
18. Schaller B. Spinal meningioma: relationship between histological subtypes and surgical outcome? J Neurooncol. 2005 Nov;75(2):157-61. [CrossRef] [PubMed]
19. Raysi Dehcordi S, Marzi S, Ricci A, Di Cola F, Galzio RJ. Less invasive approaches for the treatment of cervical schwannomas: our experience. Eur Spine J. 2012 May;21(5):887-96. [CrossRef] [PubMed] [PubMed Central]
20. Parsa AT, Lee J, Parney IF, Weinstein P, McCormick PC, Ames C. Spinal cord and intradural-extraparenchymal spinal tumors: current best care practices and strategies. J Neurooncol. 2004 Aug-Sep;69(1-3):291-318. [CrossRef] [PubMed]
21. Kane PJ, el-Mahdy W, Singh A, Powell MP, Crockard HA. Spinal intradural tumours: Part II--Intramedullary. Br J Neurosurg. 1999 Dec;13(6):558-63. [CrossRef] [PubMed]
22. Samartzis D, Gillis CC, Shih P, O’Toole JE, Fessler RG. Intramedullary Spinal Cord Tumors: Part I-Epidemiology, Pathophysiology, and Diagnosis. Global Spine J. 2015 Oct;5(5):425-35. [CrossRef] [PubMed] [PubMed Central]
23. Das JM, Hoang S, Mesfin FB. Intramedullary Spinal Cord Tumors. StatPearls Publishing; 2020.
24. Sohn S, Kim J, Chung CK, Lee NR, Park E, Chang UK, Sohn MJ, Kim SH. Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009-2012. Neurooncol Pract. 2015 Jun;2(2):93-100. [CrossRef] [PubMed] [PubMed Central]
25. Chi JH, Bydon A, Hsieh P, Witham T, Wolinsky JP, Gokaslan ZL. Epidemiology and demographics for primary vertebral tumors. Neurosurg Clin N Am. 2008 Jan;19(1):1-4. [CrossRef] [PubMed]
26. Luksanapruksa P, Buchowski JM, Zebala LP, Kepler CK, Singhatanadgige W, Bumpass DB. Perioperative Complications of Spinal Metastases Surgery. Clin Spine Surg. 2017 Feb;30(1):4-13. [CrossRef] [PubMed]
27. Atkinson RA, Jones A, Ousey K, Stephenson J. Management and cost of surgical site infection in patients undergoing surgery for spinal metastasis. J Hosp Infect. 2017 Feb;95(2):148-153. [CrossRef] [PubMed]
28. Horn SR, Dhillon ES, Poorman GW, Tishelman JC, Segreto FA, Bortz CA, Moon JY, Behery O, Shepard N, Diebo BG, Vira S, Passias PG. Epidemiology and national trends in prevalence and surgical management of metastatic spinal disease. J Clin Neurosci. 2018 Jul;53:183-187. [CrossRef] [PubMed]
29. Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27. [CrossRef] [PubMed]
30. Vialle LRG, Gokaslan ZL, Boriani S. AOSpine Masters Series. Volume 2: Primary Spinal Tumors. Thieme; 2014.
31. Conti A, Acker G, Kluge A, Loebel F, Kreimeier A, Budach V, Vajkoczy P, Ghetti I, Germano’ AF, Senger C. Decision Making in Patients With Metastatic Spine. The Role of Minimally Invasive Treatment Modalities. Front Oncol. 2019 Sep 19;9:915. [CrossRef] [PubMed] [PubMed Central]
32. Vialle LR, Gokaslan ZL, Fisher CG. AOSpine Masters Series. Volume 1: Metastatic Spinal Tumors. Thieme; 2014.
33. Barzilai O, Laufer I, Yamada Y, Higginson DS, Schmitt AM, Lis E, Bilsky MH. Integrating Evidence-Based Medicine for Treatment of Spinal Metastases Into a Decision Framework: Neurologic, Oncologic, Mechanicals Stability, and Systemic Disease. J Clin Oncol. 2017 Jul 20;35(21):2419-2427. [CrossRef] [PubMed]
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Copyright (c) 2021 Eugene G. Pedachenko , Ievgenii I. Slynko , Oleksii S. Nekhlopochyn , Anna N. Nikiforova , Viacheslav S. Botev , Tetyana A. Yovenko
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