Clinical case of five-year local control following radiosurgery of intracranial tumors in a patient with type II neurofibromatosis




neurofibromatosis type II, intracranial tumor, stereotactic radiosurgery


Type II neurofibromatosis (NF2) is a rare autosomal dominant hereditary disease characterized by the presence of many benign tumors of the nervous system. Stereotactic radiosurgery (SRS) is a generally accepted therapeutic option for sporadic vestibular schwannoma and small and medium-sized meningiomas, which allows treating several tumors simultaneously during a single irradiation session. At the same time, opinions on the use of radiosurgery as the primary treatment for patients with NF2 remain controversial. This article deals with a clinical case of the results of radiosurgical treatment of a 50-year-old patient with NF2, with a follow-up period of 5 years. The final results of SRS in ensuring local control of NF2 associated with vestibular schwannoma and meningiomas should be evaluated not earlier than 24–36 months after irradiation. The advantages of radiosurgical treatment of patients with NF2 include non-invasiveness, the possibility of irradiating several tumors in a single irradiation session, treatment under outpatient conditions, ensuring local control of tumor growth, minimizing of the neurological deficit associated with the treatment toxicity, ensuring the quality of life of patients.

Author Biographies

Olga Y. Chuvashova, Romodanov Neurosurgery Institute, Kyiv

Department of Neuroradiology and Radioneurosurgery

Andriy B. Gryazov, Romodanov Neurosurgery Institute, Kyiv

Department of Radioneurosurgery

Oksana V. Zemskova, Romodanov Neurosurgery Institute, Kyiv

Department of Radioneurosurgery

Andriy O. Bondarenko, Romodanov Neurosurgery Institute, Kyiv

Department of Radioneurosurgery


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How to Cite

Chuvashova, O. Y., Gryazov, A. B., Zemskova, O. V., & Bondarenko, A. O. (2019). Clinical case of five-year local control following radiosurgery of intracranial tumors in a patient with type II neurofibromatosis. Ukrainian Neurosurgical Journal, 25(2), 40–45.



Case Report