Experimental morphological and biochemical substantiation of cryopreserved embryonal nervous cells application in epilepsy surgical treatment

Authors

  • V. I. Sipity Kharkov State Medical University, Kharkov, Ukraine
  • O. V. Kochin Kharkov State Medical University, Kharkov, Ukraine
  • A. Yu. Petrenko Institute of Cryobiology and Cryomedicine, NAS Ukraine, Kharkov, Ukraine

DOI:

https://doi.org/10.25305/unj.135578

Keywords:

epilepsy, neurotransplantation, experimental model

Abstract

Morphological and biochemical research of the shifts occuring in epileptic rats brain under the action of cryopreserved embryonic nervous cells suspension's transplantation in the area of the experimental penicillin epileptic center in a hippocampus is carried out.

It is shown, that cryopreserved embryonic nervous cells not only keep viability after a transplantation, but also able to neuronal differentiation.

The transplantation of cryopreserved embryonic nervous cells renders essential influence on the maintenance of biogenic amines in a brain stem of epileptic rats. The downstroke of the dopamine and serotonin maintenance to subnormal levels is observed, that it is possible to survey as an attribute of convulsive readiness decrease. Besides, the neurotransplantation causes the essential increase of audiogenic convulsive readiness threshold.

References

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How to Cite

Sipity, V. I., Kochin, O. V., & Petrenko, A. Y. (2005). Experimental morphological and biochemical substantiation of cryopreserved embryonal nervous cells application in epilepsy surgical treatment. Ukrainian Neurosurgical Journal, (1), 52–56. https://doi.org/10.25305/unj.135578

Issue

No. 1 (2005)

Section

Original articles

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Copyright (c) 2005 V. I. Sipity, O. V. Kochin, A. Yu. Petrenko

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