Immunosuppressive influence of the malignant brain tumors
DOI:
https://doi.org/10.25305/unj.130881Keywords:
імуносупресія, імунокомпетентні клітини, злоякісні пухлини головного мозкуAbstract
The basic mechanisms of brain tumors of different genesis influence on the immune system are discussed. Huge variety of immunosuppressive factors, produced by malignant brain tumors is shown.
References
Аббасова С.Г., Липкин В.М., Трапезников Н.Н., Кушлинский Н.Е. Система FAS-FASL в норме и при патологии // Вопр. биол., мед. и фармацевт. химии. — 1999. — №3. — С.3–18.
Бережная Н.М., Чехун В.Ф. Иммунология злокачественного роста. — К.: Наук. думка, 2005. — 791 с.
Гнедкова И.А. Изменения в «регуляторном звене» иммуногенеза нейроонкологических больных и их клиническое значение: Автореф. дис. … канд. мед. наук. — К., 1991. — 20 с.
Заридзе Д.Г. Эпидемиология, механизмы канцерогенеза и профилактика рака // Здоров’я України. — 2004. — №18. — С.34–35.
Зозуля Ю.П., Лісяний М.І. Нейрогенний імунодефіцит при вогнищевих ураженнях головного мозку та його клінічне значення // Журн. АМН України. — 1998. — Т.4, №1. — С.44–63.
Зубова С.Г., Окулов В.Б. Молекулярные механизмы действия фактора некроза опухолей a и трансформирующего фактора роста b в процессе ответа макрофага на активацию // Иммунология. — 2001. — №5. — С.18–22.
Лисяный Н.И., Маркова О.В., Главацкий А.Я., Бельская Л.Н. Содержание FcgRIII-положительных клеток в глиомах разной степени злокачественности // Иммунология. — 1999. — №4. — С.56–58.
Маркова О.В. Состояние естественной киллерной активности лимфоцитов периферической крови больных с опухолями головного мозга: Автореф. дис. … канд. мед. наук. — К., 1990. — 23 с.
Хонина Н.А., Центмер М.И., Леплина О.Ю. и др. Характеристика и механизмы иммунных нарушений у больных со злокачественными опухолями головного мозга // Вопр. онкологии. — 2002. — Т.48, №2. — С.196–201.
Ярилин А.А. Межклеточная кооперация при иммунном ответе. Выбор клеточной формы ответа // Иммунология. — 1999. — №1. — С.17–24.
Akasaki Y., Liu G., Chung N.H. et al. Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma // J. Immunol. — 2004. — V.173, N7. — P.4352–4359.
Ammirato M., Rao S., Granger G. Detection of TNF inhibitors (soluble receptors) in the sera and tumor cyst fluid of patients with malignant astrocytomas of the brain // Front. Biosci. — 2001. — N6. — P.17–24.
Bakshi A., Nag T.C., Wadhwa S. et al. The expression of nitric oxide synthases in human brain tumours and peritumoral areas // J. Neurol. Sci. — 1998. — V.155, N5. — P.196–203.
Beck C., Schreiber H., Rowley D. Role of TGF-beta in immune-invasion of cancer // Microsc. Res. Tech. — 2001. — V.52, N4. — P.32–38.
Botti C., Seregni E., Ferrari L. et al. Immunosuppressive factors: role in cancer development and progression // Int. J. Biol. Markers. — 1998. — V.13, N2. — P.51–69.
Chahlavi A., Rayman P., Richmond A.L. et al. Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70 // J. Neuroimmunol. — 2005. — V.162, N1–2. — P.28–42.
Couldwell W.T., Dore-Duffy P., Apuzzo M.L., Antel J.P. Malignant glioma modulation of immune function: relative contribution of different soluble factors // J. Neuroimmunol. — 1991. — V.33, N8. — P.89–96.
Deng Q.J., Mao B.Y., Zhang S.F. et al. Expression and clinical significance of cyclooxygenase-2 inmedulloblastoma // Sichuan Da Xue Xue Bao Yi Xue Ban. — 2004. —V.35, N5. — P.641–643.
Didenko V.V., Ngo H.N., Minchew C., Baskin D.S. Apoptosis of T lymphocytes invading glioblastomas multiforme: a possible tumor defense mechanism // J. Neurosurg. — 2002. — V.96, N3. — P.580–584.
Dix A.R., Brooks W.H., Roszman T.L., Morford L.A. Immune defects observed in patients with primary malignant brain tumors // J. Neuroimmunol. — 1999. — V.100, N1–2. — P.216–232.
DuBois R. N., Awad J., Morrow J. et al. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-b and phorbol ester // J. Clin. Invest. — 1994. — N93. — P.493–498.
Falsig J., Latta M., Leist M. et al. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD-95-driven apoptosis // J. Neurochem. — 2004. — V.88, N1. — P.181–193.
Frankel B., Longo S.L., Ryken T.C. Human astrocytomas co-expressing Fas and Fas ligand also produce TGFbeta2 and Bcl-2 // J. Neurooncol. — 1999. — V.44, N3. — P.205–212.
Hahne M., Rimoldi D., Schroter M. et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implication for tumor immune escape // Science. — 1996. — V.274, N5291. — P.1363–1366.
Hegardt P., Widegren B., Li L. et al. Nitric-oxide-dependent systemic immunosuppression in animals with progressively growing malignant gliomas // Cell. Immunol. — 2000. — V.200, N2. — P.116–127.
Held-Feindt J., Mentlein R. CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors // Int. J. Cancer. — 2002. — V.98, N3. — P.352–356.
Hishii M., Nitta T., Ishida H. et al. Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro // Neurosurgery. — 1995. — V.37, N6. — Р.1160–1166.
Huettner C., Paulus W., Roggendorf W. Messenger RNA expression of the immunosuppressive cytokine IL-10 inhuman gliomas // Am. J. Pathol. — 1995. — V.146, N2. — P.317–322.
Kjellman C., Olofsson S.P., Hansson O. et al. Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma // Int. J. Cancer. — 2000. — V.89, N3. — P.251–258.
Leitlein J., Aulwurm S., Waltereit R. et al. Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases // J. Immunol. — 2001. — V.15, N12. — P.7238–7243.
Lim S.C. Fas-related apoptosis in gastric adenocarcinoma // Oncol. Rep. — 2003. — V.10, N1. — P.57–63.
Nakano Y., Kuroda E., Kito T. et al. Induction of macrophagic prostaglandin E2 synthesis by glioma cells // J. Neurosurg. — 2006. — V.104, N4. — P.574–582.
Nitta T., Hishii M., Sato K., Okumura K. Selective expression of interleukin-10 gene within glioblastoma multiforme // Brain Res. — 1994. — N27. — P.122–128.
Рairet M., Engelhardt G. Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: possible physiological and therapeutic implications // Clin. Pharmacol. — 1996. — N10. — P.1–17.
Prins R.M., Incardona F., Lau R. et al. Characterization of defective CD4-CD8- T cells in murine tumors generated independent of antigen specificity // J. Immunol. — 2004. — V.172, N3. — P.1602–1611.
Riffkin C.D., Gray A.Z., Hawkins C.J. et al. Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction // Neurooncol. — 2001. — N4. — P.229–240.
Saas P., Walker M., Hahne A. et al. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? // J. Clin. Invest. — 1997. — N99. — P.1173–1186.
Schwartz R. Models of T cell anergy: is there a common molecular mechanism? // J. Exp. Med. — 1996. — V.184, N1. — P.1–8.
Sharma S., Stolina M., Yang S.C. et al. Tumor cyclooxygenase 2-depend suppression of dendritic cell function // Clin. Cancer Res. — 2004. — V.11, N3. — P.328–339.
Shinoda J., Whittle I.R. Nitric oxide and glioma: a target for novel therapy? // Br. J. Neurosurg. — 2001. — V.15, N3. — P213–220.
Shono T., Tofilon P.J., Bruner J.M. et al. Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations // Cancer Res. — 2001. — V.61, N11. — P.4375–4381.
Wischhusen J., Gundram J., Radovanovic I. et al. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma // Cancer Res. — 2002. — V.62. — P.2592–2599.
Yang B.C., Lin H.K., Hor W.S. et al. Mediation of enhanced transcription of the IL-10 gene in T cells, upon contact with human glioma cells, by Fas signaling through a protein kinase A-independent pathway // J. Immunol. — 2003. — N15. — Р.3947–3954.
Ziets C., Rumpler U., Sturzl M., Lohrs U. Inverse relation of Fas-ligand and tumor-infiltrating lymphocytes in angiosarcoma: indications of apoptic tumor counterattack // Am. J. Pathol. — 2001. — V.159, N3. — P.963–970.
Zou J.P., Morford L.A., Chougnet C. et al. Human glioma-induced immunosuppression involves soluble factor(s) that alters monocytes cytokine profile and surface markers // J. Immunol. — 1999. — V.162. — P.4882–4892.
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