Survival rates in patients with the newly diagnosed glioblastoma: Data from the National Cancer Registry of Ukraine, 2008-2016




glioblastoma, survival, surgery, chemotherapy, radiotherapy, elderly


Objective. In the current study, we present the results of the survival analysis of patients with newly diagnosed glioblastoma (GBM) in Ukraine.

Materials and methods. A total of 3763 cases of patients with histologically confirmed newly diagnosed GBM who were treated over a 9-year period (2008 – 2016) were included. All patients were grouped as younger adults (<45 years at diagnosis) – 734 (19.5%) cases, middle-aged (45–64 years) – 2360 (62.7%), and older adults (>64 years) – 669 (17.8%). Clinical parameters and survival rates were defined for every three 3-year periods: 2008-2010, 2011-2013, and 2014-2016.

Results. The overall median survival was 12.2±0.2 months. Higher survival rate was observed in young adults 17.4±1.4 months (p<0.001). The hazard ratio (HR) of middle-aged group was 1.79 (95% CI 1.60-2.00; p=0.017) and for older age – 1.51 (95% CI 1.32-1.72; p<0.001). The patients treated in the second period achieved better prognosis with a median survival in 12.6±0.3 months (p<0.001) with HR 0.75, 95% CI 0.66-0.85; p<0.01). The median overall survival in combined treatment protocol group was 16.3±0.5 months, and the worst prognosis was in surgery alone group – 7.5±0.3 months (p<0.001). The HR for surgery with radiotherapy was 1.36 (95% CI 1.22-1.51; p<0.001), and for surgery alone it raised up to 1.94 (95% CI 1.73-2.17; p<0.001). The HR for a combination of surgery with chemotherapy was 1.18 (95% CI 0.90-1.53; p<0.001), but it was not significant (p=0.25).

Conclusions. The using of combined treatment including surgery and chemoradiotherapy was associated with survival advantage for all age groups and time periods.

Author Biographies

Artem V. Rozumenko, Romodanov Neurosurgery Institute, Kyiv

Neuro-Oncology Department

Valentyn M. Kliuchka, Romodanov Neurosurgery Institute, Kyiv

Neuro-Oncology Department

Volodymir D. Rozumenko, Romodanov Neurosurgery Institute, Kyiv

Neuro-Oncology Department

Zoja P. Fedorenko, National Cancer Institute, Kyiv

National Cancer Registry of Ukraine


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How to Cite

Rozumenko, A. V., Kliuchka, V. M., Rozumenko, V. D., & Fedorenko, Z. P. (2018). Survival rates in patients with the newly diagnosed glioblastoma: Data from the National Cancer Registry of Ukraine, 2008-2016. Ukrainian Neurosurgical Journal, (2), 33–39.



Original articles