The study of antibodies level to glial tumours antigens in blood of neurooncological patients
DOI:
https://doi.org/10.25305/unj.108633Keywords:
brain tumors, antibodies, serumAbstract
The level of antibodies to tumor tissue at patients with brain tumors was studied using enzyme-linked immunosorbent assay with tumor cells.
Antibodies to antigens of glial tumors were found in the blood of neurooncological patients. The highest level of antibodies was determined in the blood of patients with glioblastoma, the lowest one — with astrocytoma of II grade of anaplasia and oligodendroglioma. A weak interaction of serum of patients with glioblastoma with antigens of astrocytoma and oligodendroglioma cells was found. A high level of antibodies to antigens of glioblastomа cells reflects the intensive Th-2 specific immune humoral answer.
References
Бережная Н.М., Чехун В.Ф. Система интерлейкинов и рак. — К.: Диа, 2000. — 224 с.
Бережная Н.М., Чехун В.Ф. Иммунология злокачественного роста. — К.: Наук. думка, 2005. — 791 с.
Руководство по культивированию нервной ткани. Методы. Техника. Проблемы / В.П. Божкова, Л.А. Брежетовский, В.М. Буравлев и др. — М.: Наука, 1988. — 318 с.
Виноградова Ю.Е., Леках И.В., Варламова Е.Ю. и др. Естественные аутоантитела у больных с Т-клеточными лимфатическими опухолями // Иммунология. — 2008. — №1. — С.31–34.
Гнедкова И.А. Изменение в регуляторном звене иммуногенеза у нейроонкологических больных и их клиническое значение: Автореф. дис. ... канд. мед. наук. — К., 1991. — 18 с.
Кеда Ю.М., Крюкова И.В., Смирнова О.М. и др. Маркеры гуморального аутоиммунитета при аутоиммунных эндокринных заболеваниях // Вестн. РАМН. — 1994. — №12. — С.33–39.
Королева Е.П., Лагарькова М.А., Хлгатян С.В. и др. Серологические исследования репертуара раковых антигенов и аутоантигенов человека // Молек. біологія. — 2004. — Т.38, №2. — С.233–238.
Лисяный Н.И. Изменение иммунных реакций при различных видах глиом // Глиомы головного мозга. — К.: УИПК „ЕксОб”, 2007. — С.235–253.
Лісяний М.І., Любич Л.Д. Механізми імунонейропатологічних процесів при дії радіаційного опромінення. — К.: Віпол, 2001. — 198 с.
Лісяний М.І., Розуменко В.Д., Скітяк С.А. Особливості імунного цитокінового статусу у хворих з гліомами головного мозку // Укр. нейрохірург. журн. — 2001. — №1. — С.24–31.
Маркова О.В. Состояние естественной киллерной активности лимфоцитов периферической крови больных с опухолями головного мозга: Автореф. дис. ... канд. мед. наук. — К., 1990. — 19 с.
Boon T., van den Eynde B. Tumour immunology // Curr. Opin. Immunol. — 2003. — V.15. — P.129–130.
Beaty M.W., Fetsch P., Wilder A.M. et al. Effusion cytology of malignant melanoma: a morphologic and immunocytochemical analysis including application of the MART-1 antibody // Cancer (Cancer Cytopathol.). — 1997. — V.81. — P.57.
Buckley N., Bates A.S., Broome J.C. p53 protein accumulates in Cushing adenomas and invasive non-functional adenomas // J. Clin. Endocrinol. — 1994. — V.79. — P.1513–1516.
Chen Y.T., Scanlan M.J., Sahin U. et al. A testicular antigen aberrantly expressed in human cancer detected by aytologeous antibody screening // Proc. Natl. Acad. Sci. USA. — 1997 — V.94. — P.1914–1918.
De Bellis A., Bizzaro A., Bellastella A. Pituitary antibodies and lymphocytic hypophysis // Best Pract. Res. Clin. Endocrinol. Metab. — 2005. — V.19, N1. — P.67–84.
de Vries J.E., van Benthen M. Separation of viable from nonviable tumor cells by flatation a ficoll friosil mixture // Transplantation. — 1973. — V.15, N4. — P.409–410.
De Vries T.J., Fourkour A., Wobbes T. et al. Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1 and tyrosinase in human melanoma cell lines and in human melanocytic lesions // Cancer Res. — 1997. — V.57. — P.3223.
Erdile L.F., Smith D., Berd D. Whole cell ELISA for detection of tumor antigen expression in tumor samples // J. Immunol. Methods. — 2001. — V.258. — P.47–53.
Kobayeshi T., Yamaka R., Homma J. et al. Tumor mRNK loaded dendritic cell elicit tumor specific CD-8(+) cytotoxic T-cells in patients with malignant glioma // Cancer Immunol. Immunother. — 2003. — V.53, N3. — P.632–637.
Louis D.N., Ohgaki H., Wiestler O.D. WHO Classification of tumours of the Central Nervous System. —Lyon: International Agency for Research on Cancer, 2007. — 312 p.
Scanlan M.J., Chen Y.T., Williamson B. et al. Characterization of human colon cancer antigens recognized by autologous antibodies // Int. J. Cancer. — 1998. — V.76. — P.652–658.
Wischhusen J., Gundram J., Radovanovic I. et al. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma // Cancer Res. — 2002. — V.62. — P.2592–2599.
Zou J.P., Morford L.A., Chougnet C. et al. Human glioma-induced immunosuppression involves soluble factor(s) that alters monocytes cytokine profile and surface markes // J. Immunol. — 1999. — V.162. — P.4882–4892.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2009 N. I. Lisyany, L. N. Belska, V. D. Rozumenko, A. I. Potapova
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.
