Ultrastructural peculiarities of the organization process in a zone of spinal cord traumatic injury and synthetic macropourus hydrogel implantation

Authors

  • V. I. Tsymbalyuk Romodanov Neurosurgery Institute, Kiev, Ukraine
  • A. T. Nosov Romodanov Neurosurgery Institute, Kiev, Ukraine
  • V. M. Semenova Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Yu. Ya. Yaminsky Romodanov Neurosurgery Institute, Kiev, Ukraine
  • V. V. Vaslovich Romodanov Neurosurgery Institute, Kiev, Ukraine
  • V. V. Medvedev Romodanov Neurosurgery Institute, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.108013

Keywords:

experimental traumatic spinal cord injury, renewing neurosurgery, synthetic macropourus hydrogel, astrocytes, fibroblasts, axonal growth, myelinisation

Abstract

Ultrastructural features of the tissue organization process in a zone of rat’s spinal cord left-side partial cut and immediate synthetic macropourus hydrogel implantation were investigated. During first three weeks after injury modelling the implantant produces gentle conjunctive tissue which keeps going for some more months, and that offers favorable conditions for regenerative growth of neural fibre of small and middle diameter. At animals from control group the spinal cord traumatic injury zone organization conducted with the help of primarily glial components that led to a quick formation of compact gliofibrotic scar. At later observation terms gentle conjunctive tissue in the gel was replaced by rude fibre-like components that was accompanied by delayed degeneration of some myelinated fibres.

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Published

2009-12-30

How to Cite

Tsymbalyuk, V. I., Nosov, A. T., Semenova, V. M., Yaminsky, Y. Y., Vaslovich, V. V., & Medvedev, V. V. (2009). Ultrastructural peculiarities of the organization process in a zone of spinal cord traumatic injury and synthetic macropourus hydrogel implantation. Ukrainian Neurosurgical Journal, (4), 51–56. https://doi.org/10.25305/unj.108013

Issue

No. 4 (2009)

Section

Original articles

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Copyright (c) 2009 V. I. Tsymbalyuk, A. T. Nosov, V. M. Semenova, Yu. Ya. Yaminsky, V. V. Vaslovich, V. V. Medvedev

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