Поліморфізм глутатіонтрансфераз в гліомах головного мозку людини та їх значення для прогнозу ефективності хіміотерапії

I. G. Vasilyeva; V. D. Rozumenko; A. Ya. Glavatsky; N. G. Chopick; N. P. Olexenko; E. S. Galanta; O. I. Tsyubko; N. D. Snitsar

doi:10.25305/unj.108009

Authors

I. G. Vasilyeva Romodanov Neurosurgery Institute, Kiev, Ukraine
V. D. Rozumenko Romodanov Neurosurgery Institute, Kiev, Ukraine
A. Ya. Glavatsky Romodanov Neurosurgery Institute, Kiev, Ukraine
N. G. Chopick Romodanov Neurosurgery Institute, Kiev, Ukraine
N. P. Olexenko Romodanov Neurosurgery Institute, Kiev, Ukraine
E. S. Galanta Romodanov Neurosurgery Institute, Kiev, Ukraine
O. I. Tsyubko Romodanov Neurosurgery Institute, Kiev, Ukraine
N. D. Snitsar Romodanov Neurosurgery Institute, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.108009

Keywords:

brain gliomas, chemoresistance, glutathione S-transferases

Abstract

Glutathione S-transferases common activity, genotypes of glutathione transferases mu and theta and also levels of glutathione transferase pi expression in human brain gliomas (80 samples: 10 low-grade diffuse astrocytomas, 19 anaplastic astrocytomas, 37 glioblastomas, 9 oligodendroastrocytomas, 5 oligodendrogliomas) of different malignancy grade were investigated. The results of conducted researches testified that functional polymorphism of GSTP1 glutathione S-transferases activity correlated with gliomas malignancy grade. Structural polymorphism of GSTM1 and GSTT1 did not depend on the malignancy grade. However, it was set that GSTМ1“0”-genotype presence was more frequent in astrocytomas. Thus, for effective chemotherapy it is necessary to take into account individual features of glutathione transferases dependent chemoresistance.

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