Role of nitric oxide in the cerebrospinal fluid by subarachnoid hemorrhage and vasospasm
Keywords:
nitric oxide, nitrite, subarachnoid hemorrhage, cerebral vasospasm, cerebral spinal fluid, delayed cerebral ischemiaAbstract
The role of nitric oxide (NO) in the pathogenesis of delayed cerebral vasospasm (VS) and cerebral ischemia after subarachnoid hemorrhage (SAH) was investigated by analyzing the stable metabolites of NO — nitrite by Griess method in the cerebrospinal fluid (CSF) 45 patients with SAH compared with patients of nonruptured aneurysms. The levels of nitrite in CSF before surgery treatment and in CSF obtained daily from the cisternai drainage after surgery significantly increased with time and were higher than those of control patients, but in the patients with severe VS the levels nitrite transiently decreased on 4–9 days. Decreased levels nitrite in the CSF may be an indicator of the presence of VS and delayed ischemic complication due to SAH.References
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