Electroneuromyographic correlates of sciatic nerve function restoration after its resection and welded epineural coaptation in the experiment


  • Vitaliy I. Tsymbaliuk Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-7544-6603
  • Vitaliy Y. Molotkovets Bogomolets National Medical University, Kyiv, Ukraine
  • Volodymyr V. Medvediev Bogomolets National Medical University, Kyiv, Ukraine
  • Borys M. Luzan Bogomolets National Medical University, Kyiv, Ukraine
  • Lesia S. Turuk Національний медичний університет імені О.О. Богомольця МОЗ України, Київ, Ukraine
  • Мykhaylo М. Tatarchuk Romodanov Neurosurgery Institute, Kyiv, Ukraine
  • Natalya G. Draguntsova Romodanov Neurosurgery Institute, Kyiv, Ukraine




neurotomy, neurorrhaphy, welding coaptation of biological tissues, electroneuromyography, peripheral nerve regeneration


Objective: To estimate the effectiveness of welding epineural coaptation of the residual sciatic nerve after resection based on electroneuromyographic (ENMG) parameters obtained in the gastrocnemius muscle.

Materials and methods. Experimental animals were albino outbreed male rats (350–450 g, 7 months old); trauma model was the resection of the left sciatic nerve in the middle third; the experimental groups were as following: 1 — neurotomy (n = 18), 2 — neurotomy + neurosuture (n = 13), 3 — neurotomy + welding coaptation (n = 15); the method of investigation was direct needle ENMG (sciatic nerve stimulation, responses were registered in gastrocnemius muscle) in 3 and 5 months after injury.

Results. The model of the nerve trauma with a temporary restriction of limb mobility is relevant for evaluating the effectiveness of restorative interventions in this type of pathology. In 5 months of observation there was found a significant prevalence of M-response amplitude in the injured limb compared to neurorrhaphy (17.3 ± 2.3 vs. 8.4 ± 0.9 mV, respectively; p = 0.005). M-response amplitude lateralization after the welded coaptation, in contrast to neurorrhaphy, is of temporary nature, indicating the improved regeneration process. Absence of ENMG-indices lateralization in 3 and 5 months after the neurotomy and high values of the M-response amplitude in 5 months indicated the possibility of gastrocnemius alternative re-innervations by terminals of intact nerve trunks.

Conclusion. High-frequency electric epineural welding provides a reliable coaptation of the residual nerve, and, taking into account some ENMG indicators, is more effective than neurorrhaphy.

Author Biographies

Vitaliy I. Tsymbaliuk, Bogomolets National Medical University, Kyiv

Department of Neurosurgery

Vitaliy Y. Molotkovets, Bogomolets National Medical University, Kyiv

Department of Neurosurgery

Volodymyr V. Medvediev, Bogomolets National Medical University, Kyiv

Department of Neurosurgery

Borys M. Luzan, Bogomolets National Medical University, Kyiv

Department of Neurosurgery

Lesia S. Turuk, Національний медичний університет імені О.О. Богомольця МОЗ України, Київ

Department of Neurosurgery

Мykhaylo М. Tatarchuk, Romodanov Neurosurgery Institute, Kyiv

Restorative Neurosurgery Department

Natalya G. Draguntsova, Romodanov Neurosurgery Institute, Kyiv

Laboratory of Experimental Neurosurgery


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How to Cite

Tsymbaliuk, V. I., Molotkovets, V. Y., Medvediev, V. V., Luzan, B. M., Turuk, L. S., Tatarchuk М. М., & Draguntsova, N. G. (2017). Electroneuromyographic correlates of sciatic nerve function restoration after its resection and welded epineural coaptation in the experiment. Ukrainian Neurosurgical Journal, (2), 44–49. https://doi.org/10.25305/unj.104503



Original articles