Деякі закономірності забезпечення вітамінами групи В  хворих з гліальними та метастатичними пухлинами головного мозку в доопераційному періоді

Z. V. Saldan

doi:10.25305/unj.90145

Authors

Z. V. Saldan Municipal City Clinical Hospital N8, Lviv, Ukraine

DOI:

https://doi.org/10.25305/unj.90145

Keywords:

glial and metastatic brain tumors, B group vitamins, homeostasis

Abstract

General conformities to law of supplying B group vitamins in patients with primary glial and metastatic brain tumors using loading with vitamins before operation with determination of their concentration in blood serum and day’s urine were educed.
The concentration of vitamins at all patients’ blood serum and day’s urine was significantly lower than in control without dependence of brain tumor type. The additional prescribing of В1, В2 and В6 vitamins before operation allowed to save that level of excreted vitamins, which was observed at all patients after hospitalization.
At patients with glioma of 1–2 and 3–4 degrees of anaplasia and metastatic tumors and meningosarcoma the expressed deficit of B group vitamins was found out. Additional setting of group B vitamins in complex treatment led to stabilization of their exchange in organism, but did not remove their deficit. Further researches are needed for development of rational vitaminotherapy in the complex of combined treatment of patients with brain tumors.

References

Спиричев В.Б. Теоретические и практические аспекты современной витаминологии / В.Б. Спиричев // Укр. біохім. журн. — 2004. — Т.76, №4. — С.32–54.

Киричек Л.Т. Фармакология витаминов / Л.Т. Киричек // Междунар. мед. журн. — 2005. — Т.7, №4. — С.97–104.

Жвиташвили Ю.Б. Как победить рак. Выбор диеты / Ю.Б. Жвиташвили. — СПб.: Нева, 2002. — 370 с.

Молчанов О.Е. Правильное питание при онкологических заболеваниях / О.Е. Молчанов. — СПб., 2004. — 78 с.

Спиричев В.Б.Обогащение пищевых продуктов витаминами и минеральными веществами / В.Б. Спиричев, Л.Н. Шатнюк, В.М. Позднянский // Новосибирск: Сиб. универс. издание, 2004. — 547 с.

Шевага В.Н. Макро- и микроэлементы в крови и спинномозговой жидкости у больных с опухолями головного мозга / В.Н. Шевага. — Львов: Львов.гос. мед. ин-т, 1971. — 17 с.

Toxicity of isotretinoin in a chemoprevention trial to prevent second primary tumors following head and neck cancer / S.E. Benner, T.F. Pajak, J. Stetz [et al.] // J. Natl. Cancer. Inst. — 1994. — V.86 N23. — P.1799–1801.

Окислительный стресс. Прооксиданты и антиоксиданты / Е.Б. Меньщикова, В.З. Ланкин, Н.К. Зенков [и др.]. — М.: Слово, 2006. — 553 с.

Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev. 2004 / G. Bjelakovic, D. Nikolova, R.G. Simonetti [et al.] // Evid. Based Nurs. — 2005. — V.8, N2. — P.48.

Bjelakovic G. Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma / G. Bjelakovic, A. Nagorni, D. Nikolova // Aliment. Pharmacol. Ther. — 2006. — V.24, N2. — P.281–291.

Вдовиченко О.В. Забезпеченість вітамінами С, РР, В1, В2 здорових людей залежно від пори року і статі / О.В. Вдовиченко // Буковин. мед. вісн. — 2005. — Т.9, №3. — С.83–85.

Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism / F. Depeint, W.R. Bruce, N. Shangari [et al.] // Chem. Biol. Interact. — 2006. — V.163, N1–2. — P.94–112.

Harper C. Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe! / C. Harper // Eur. J. Neurol. — 2006. — V.13, N10. — P.1078–1082.

Кудрин А.В. Микроэлементы в иммунологии и онкологии. Программы института микроэлементов ЮНЕСКО / А.В. Кудрин, O.A. Громова. — М.: Гэотар-МЕД, 2007. — 970 с.

Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways / F. Depeint., W.R. Bruce, N. Shangari [et al.] // Chem. Biol. Interact. — 2006. — 163, N1–2. — P.113–132.

Perumal S.S. Energy-modulating vitamins — a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma / S.S. Perumal, P. Shanthi, P. Sachdanandam // Br. J. Nutr. — 2005. — V.93, N6. — P.901–909.

Malecka S.A. Prophylactic and therapeutic application of thiamine (vitamin B1) — a new point of view / S.A. Malecka, K. Poprawski, B. Bilski // Wiad Lek. — 2006. — V.59, N5–6. — P.383–387.

Wu S. Benfotiamine – monograph / S. Wu // Altern. Med. Rev. — 2006. — V.11, N3. — P.238–242.

Гребенникова Н.П. Витаминотерапия и витаминопрофилактика. Проблемы изобилия / Н.П. Гребенникова, В.И. Георгиев // Провизор. — 1999. — №3. — С.38–39.

Wu S. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha / S. Wu., J. Ren // Neurosci. Lett. — 2006. — V.394, N2. — P.158–162.

Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose / E. Berrone, E. Beltramo, C. Solimine [et al.] // J. Biol. Chem. — 2006. — V.281, N14. — P.9307–9313.

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis / G. Bjelakovic, D. Nikolova, L.L. Gluud [et al.] // J.A.M.A. — 2007. — V.297, N8. — P.842–857.

Jiang Y.Y. Effect of B vitamins-fortified foods on primary school children in Beijing / Y.Y. Jiang // Asia Pac. J. Publ. Health. — 2006. — V.18, N2. — P.21–25.