Connection of human cytomegalovirus and malignant gliomas of braine
DOI:
https://doi.org/10.25305/unj.61884Keywords:
HCMV, glioblastoma, development by stages interaction tumor, virus, organismAbstract
Elucidation of role HCMV in pathogenesis of glioblastomas is actual task.
Objective: To investigate the presence of HCMV in cells of glioblastomas and to compare with immunologic and hematologic exponents of peripheral blood and size of glioma and its clinical features.
Materials and methods: The presence of HCMV were examined in cells of 53 glioblastomas by means of indirect immunofluorescence with set “HCMV- monoscan” antibodies to protein pp 65 of HCMV (Russia). Proliferative answer was evaluated by means of the reaction blasttransformation on the different mutagens. Hematologic and clinical data were studied in cases reports.
Results: HCMV was examined in 39 (73%) biopsies of glioblastomasfrom studied 53 cases. It was noted more low proliferative activity of T lymphocytes and monocytes/macrophages by using test with indometacyne undoubtedly in patients with HCMV in tumor some more sire of tumor (gate of MRT) in comparison with the patients which HCMV was not determined suggesting the possibility that immune status depends from presence of virus and anaplasia grades O glioma. It discusses some definite successiveness influence of HCMV on immune status contained the alternation of stages the activization and the suppression of immune answer of gliomas different anaplasia grades. It was noted the primary immune suppression in cases of glioblastomas.
Conclusion: The presence HCMV in cells of glioblactomas correlates with suppression of T cells immune answer, this fact does not depends from age, sex, length of disease and peculiarity postoperative course. The size of tumor and more short period of remission correlates with the presence of virus in glioblastomas and rapid growth of tumor. Establishment of main links of the interaction HCMV, tumor and immune system gives the oppoturhute to use this data for the new approaches to antitumor therapy.
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Copyright (c) 2016 Nikolay Lisianyi, Irina Gnedkova, Diana Stanetskaya, Volodymyr Rozumenko, Mykhaylo Kvasha, Lyudmila Belska, Antonina Klyuchnikova, Anna Shmeleva
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