The neurotransmitters content in subarachnoid liquor in patients with infant cerebral palsy: influence of fetal tissue transplantation
Keywords:
cerebral palsy, dopamine, gamma aminobutyric acidAbstract
We analyzed the content of GABA and DA in subarachnoid liquor of patients with spastic hypercynesis form of JCP and patients with spastic tetraparesis to localise the damaded integration level in the brain functional structures. The results allowed us to devide the patients with spastic tetraparesis into three groups: —A with the high level of GABA and DA (suggested levels of damage are putamen and globus pallidus); B — with the high level of GABA and the normal level of DA (suggested level of damage is globus pallidus); C — with the normal content of GABA and DA (other levels of integration).
The patients with spastic hypercinesis form of JCP were devidet into two groups: A — with the high level of DA and the normal level of GABA (suggested damage of DA — ergic connections of substantia nigra with the putamen ); B — with the normal content of GABA and DA (other levels of integration).
The transplantation of embryonic neuron tissue in the most cases decreased the level of neurotransmiters in subarachnoid liquor, that indicate its influence on the processes of regeneration of damaged integrative connections in the cortex-, striatum-, globus pallidus- thalamocortical loop.
References
Бонецкий А. А. Федоров В.И. Определение катехоламинов плазмы крови методом ВЭЖХ на микроколоночном хроматографе «Милихром»// Лаб. дело. —1989. —№ 4. —С. 21 —25.
Завалишин И.А., Бархатова В.П. Спастичность // Журн. невропатологии и психиатрии им. С.С. Корсакова. —1997. —№ 3.—С. 68—70.
Изменения церебрального метаболизма при черепномозговой травме под влиянием трансплантации эмбриональной нервной ткани./ Зозуля Ю.А., Цымбалюк В.И., Васильева И.Г. и др. // Журн. АМН Укр.—1998.—Т.4, № 4.—С. 597—608.
Комплексное лечение пациентов с паркинсонизмом с использованием живых фетальных клеток/ Миронов Н.В., Шмырев В.И. и др. // Трансплантация фетальных тканей и клеток. БЭБМ. —1998.—Т.126.—Прил.1.—С. 63—68.
Предварительная оценка результатов метода трансплантации эмбриональных тканей в неврологии / Волошин П.В., Грищенко В.И., Черненков В.Г. и др. // Трансплантация фетальных тканей и клеток. БЭБМ. —1998.—Т.126.—Прил.1.—С. 78—79.
Трансплантация фетальных тканей и клеток человека // Васильев Н.В., Коляда Т.И., Волянский Ю.Л. и др. —М.,1996.—С. 28—30.
Хмелевский Ю.В., Усатенко О.К. Основные биохимические константы человека в норме и патологии .—К.: Здоров’я,1987.—160 c.
Цветанова Е. М. Ликворология. — К.: Здоров’я, 1986.—370 c.
Alexander G.E., Crutcher M.D. Functional architecture of basal ganglia ciruits: neural substrates of parallel processing // Trends Neurosci. —1990. —V.13, N7. —P. 266—271.
Chevalier G., Deniau J.M. Disingibition as a basic process in the expression of striatal functions // Trends Neurosci. —1990. —V.13. —№ 7. —P. 277—280.
De Long M.R. Primate models of movement disorders of basal ganglia origin //Trends Neurosci. —1990. —V.13, N7. —P. 281—285.
Graybiel A.M. Neurotransmitters and neuromodulators in the basal ganglia// Trends Neurosci. —1990. —V.13, N7. —P. 244 —254.
Lindgren S., Andrem M., Grabovsko M. A fluorimetric metod for determination of GABA in tissues following cation exchange chromatography acid condensation with o-phtulaldehyde // J. Neurоl Transmission. —1982. —V.55, N4. —P. 243—252.
Nelson K.B. Causes of cerebral palsy // Curr. Opin. Pediatr.—1999. —V. 11, N6. —P. 487—491.
Parent A. Extrinsic connections of the basal ganglia // Trends Neurosci.—1990. —V.13, N7. —P. 254—258.
Smith A. D., Bolam. J.P. The neural network of the basal ganglia as revealed by the study of synaptic connectios of identified neurones //Trends Neurosci.—1990. —V.13, N7. —P.259—265.
Winkler C., Bentlage C., Nikkhah G., Samii M. Bjorklund A. Intranigral transplantants of GABA-rich striatal tissue induce behavioral recovery in the rat parkinson model and promote the effects obtained by intrastriatal dopaminergic transplantants //Exp. Neurol. —1999. —V.155, N2. —P. 165—86.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2001 Vitaliy Tsymbaliuk, Irina Vasileva, Leonid Pichkur, Nataliya Chopik, Olga Tsubko, Nataliya Pichkur, Elena Galanta
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.
