Outlook for the treatment and prognosis of high-grade brain gliomas

Yuriy Chomolyak, Volodymyr Smolanka, Taras Studenyak

Abstract


Malignant gliomas account up to 38% of primary brain tumors and tend to grow up for the last 30 years. The median survival time for patients with glioblastomas after surgery, followed by a combination of radiation and chemotherapy is 14.6 months. The standard for surgical treatment of malignant gliomas is their maximal safe resection. Increase resection provides patients’ survival increasing, but there are no randomized controlled trials on this subject. For the last years significant progress was marked in understanding of pathogenesis mechanisms of malignant gliomas that opens new possibilities for their treatment improvement. The purpose of the report was to analyze the modern advances in treatment of patients with high-grade brain gliomas and to identify promising directions for future researches. Modern features of surgical treatment as well as additional methods (radiation and chemotherapy) were considered, promising researches were identified.

Keywords


high-grade gliomas; glioblastoma; anaplastic astrocytoma; anaplastic oligodendroglioma; oligoastrocytoma; cytoreduction; targeted therapy; biomarkers

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DOI: https://doi.org/10.25305/unj.54140

Copyright (c) 2013 Yuriy Chomolyak, Volodymyr Smolanka, Taras Studenyak

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