The first experience of autologous chondrocytes transplantation after lumbar microdiscectomy

Authors

  • Eugene Pedachenko Romodanov Neurosurgery Institute, Kiev, Ukraine https://orcid.org/0000-0003-4759-6019
  • Mykhaylo Khyzhnyak Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Kostyantyn Gorbatyuk Department of Miniinvasive and Laser Spinal Neurosurgery, Romodanov Neurosurgery Institute, Kiev; Neurosurgical Department, Vinnitsa Regional Psychoneurological Hospital, Vinnitsa, Ukraine
  • Yuriy Pedachenko Department of Miniinvasive and Laser Spinal Neurosurgery, Romodanov Neurosurgery Institute, Kiev; Department of Neurosurgery, Shupyk National Medical Academy of Postgraduate Education of Ministry of Healthcare of Ukraine, Kiev, Ukraine
  • Elena Krasilenko Romodanov Neurosurgery Institute, Kiev; Institute of Nuclear Medicine and Diagnostic Radiology, Kiev, Ukraine
  • Volodymyr Shabliy Romodanov Neurosurgery Institute, Kiev; Institute of Cell Therapy, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.46601

Keywords:

intervertebral disc, hernia, autologous chondrocytes, transplantation

Abstract

The purpose. To develop and provide into clinical practice the hi-tech method of autologous chondrocytes transplantation for treatment of patients with intervertebral discs herniation after lumbar microdiscectomy.

Material and methods. The chondrocytes were isolated from tissues of intervertebral disc hernia, cultivated and preserved, and administrated as percutaneous puncture in the operated intervertebral disc (3 months after microdiscectomy).

We plan to study the influence of transplanted autologous chondrocytes on renewing of intervertebral disc height and function (according to clinical methods, X-ray and MRI).

Results. In 6 patients autologous chondrocytes transplantation was performed. There were no complications or by-effects.

Conclusions. Autotransplantation of chondrocytes in patients after lumbar microdiscectomy is safe and perspective method of surgical treatment at degenerative spine diseases and requires further study.

Author Biographies

Eugene Pedachenko, Romodanov Neurosurgery Institute, Kiev

Department of Miniinvasive and Laser Spinal Neurosurgery,

Mykhaylo Khyzhnyak, Romodanov Neurosurgery Institute, Kiev

Department of Miniinvasive and Laser Spinal Neurosurgery

Elena Krasilenko, Romodanov Neurosurgery Institute, Kiev; Institute of Nuclear Medicine and Diagnostic Radiology, Kiev

Department of Miniinvasive and Laser Spinal Neurosurgery; Department of General Practice

Volodymyr Shabliy, Romodanov Neurosurgery Institute, Kiev; Institute of Cell Therapy, Kiev

Department of Miniinvasive and Laser Spinal Neurosurgery

References

Battié M. Lumbar Disc Degeneration: Epidemiology and Genetics. The Journal of Bone and Joint Surgery (American). 2006;88(suppl_2):3. CrossRef

Shimer A, Chadderdon R, Gilbertson L, Kang J. Gene Therapy Approaches for Intervertebral Disc Degeneration. Spine. 2004;29(23):2770-2778. CrossRef

An H, Thonar E, Masuda K. Biological Repair of Intervertebral Disc. Spine. 2003;28(supplement):S86-S92. CrossRef

Chan D, Song Y, Sham P, Cheung K. Genetics of disc degeneration. European Spine Journal. 2006;15(S3):317-325. CrossRef

Wallach C, Gilbertson L, Kang J. Gene Therapy Applications for Intervertebral Disc Degeneration. Spine. 2003;28(supplement):S93-S98. CrossRef

Roughley P.J. Parameters that influence change in nucleus pulposus composition. Spine. 2004;29:2691–2699.

Yoon S, Patel N. Molecular therapy of the intervertebral disc. European Spine Journal. 2006;15(S3):379-388. CrossRef

Kovac D, Rotim K, Kovac V, Perović D, Kvesić D, Cerina V, Bozić B, Ivanec Z, Radić I, Cimić M, Lakicevic G, Borić M, Petrović T. [New techniques and prospects in invasive treatment in vertebrology]. Lijec Vjesn. 2011;133(3-4):125-132. Croatian. PubMed

Anderson D, Markova D, An H et al. Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells in the Cultured Rabbit Intervertebral Disc. American Journal of Physical Medicine & Rehabilitation. 2013;92(5):420-429. CrossRef

Vadalà G, Sowa G, Hubert M, Gilbertson L, Denaro V, Kang J. Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation. J Tissue Eng Regen Med. 2011;6(5):348-355. CrossRef

Richardson S, Hoyland J, Mobasheri R, Csaki C, Shakibaei M, Mobasheri A. Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. Journal of Cellular Physiology. 2010;222(1):23-32. CrossRef

Coric D, Pettine K, Sumich A, Boltes MO. Prospective study of disc repair with allogeneic chondrocytes presented at the 2012 Joint Spine Section Meeting. J Neurosurg Spine. 2013;18(1):85-95. CrossRef

Wang F, Wu X, Wang Y, Bao J. Research situation of stem cells transplantation for intervertebral disc degeneration. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013;27(5):575-579. Chinese. PubMed

Grunert P, Gebhard H, Bowles R et al. Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine. Journal of Neurosurgery: Spine. 2014;20(4):443-451. CrossRef

Meisel H.J, Bertagnoli R. ,Mayer M. EuroDISC Study — Assessment of efficacy/safety of sequestrectomy + autologous disc chondrocytes: 2nd interims analysis. In: Abstr. 2nd International Congress Biotechnologies for Spinal Surgery (Leipzig, 20–22 Sept., 2007). Leipzig. 2007. P.40.

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Published

2014-12-24

How to Cite

Pedachenko, E., Khyzhnyak, M., Gorbatyuk, K., Pedachenko, Y., Krasilenko, E., & Shabliy, V. (2014). The first experience of autologous chondrocytes transplantation after lumbar microdiscectomy. Ukrainian Neurosurgical Journal, (4), 46–49. https://doi.org/10.25305/unj.46601

Issue

No. 4 (2014)

Section

Original articles

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Copyright (c) 2014 Eugene Pedachenko, Mykhaylo Khyzhnyak, Kostyantyn Gorbatyuk, Yuriy Pedachenko, Elena Krasilenko, Volodymyr Shabliy

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