The molecular-genetic changes, induced by medulloblastoma
Keywords:
medulloblastoma, molecular-genetic disordersAbstract
The chromosomas-genetis changes in medulloblastoma cells were discussed. It was determined, that the most frequent disturbances were manifested in 17 and 22 chromosomas, in which the oncosupressive genes were localized.
The medulloblastoma genes amplication is characterised by the amplification of myc-1,2,x, Erb-2, Trk genes, which are correspond to the proliferation, and also by mutation the suppressive genes р53, p16.
Medulloblastomas are accompanied wih the disturbances in differentiation’s signal way genes and Path-genes. The role of this genes in metastasis and continual growth were also discussed.
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