The content of middle-weight molecules in the peripheral blood of patients with brain tumors of different histostructure

Nikolai I. Lisyanyi, Ludmila N. Belskaya, Diana N. Stanetskaya, Antonina I. Potapova

Abstract


Background. In tumor processes in the body the local inflammatory reactions occur, antitumor immunity is impaired and various low-molecular factors level increases in peripheral blood, particular middle-weight molecules (MWM).The content and nature of these substances depends on the characteristics of pathological processes in the body.

Aim was to determine the blood MWM level in patients with brain tumors.

Materials and methods. The study included 39 blood samples of patients with brain tumors and 11 blood samples of healthy people. MWM level was determined by NI Gabrielyan method with spectrophotometric determination at a wave length of 254 and 280 nm. The results were processed using statistical methods.

Results. The patients with brain tumors were found to have increased MWM level in peripheral blood compared to healthy individuals, especially when set at 254 nm. MWM level depended on tumors histostructure with slightly higher concentration in glial tumors and pituitary adenomas compared to meningioma and metastases.

Conclusion. MWM level in the blood of patients with brain tumors depends on tumor nature and may serve as an indicator of inflammatory and metabolic processes in the body in the combined modality treatment of brain tumors.


Keywords


brain tumors; middle-weight molecules

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DOI: https://doi.org/10.25305/unj.112092

Copyright (c) 2017 Nikolai I. Lisyanyi, Ludmila N. Belskaya, Diana N. Stanetskaya, Antonina I. Potapova

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