Neurotrophins expression in human brain from embryonic weeks 5–9
Keywords:
nerve growth factor, brain-derived neurotrophic factor origin, neurotrophin-3, neurotrophin-4/5, ciliary neurotrophic factor, glial derived neurotrophic factor, embryonic human brainAbstract
The chemical surrounding play a crucial role in determination of phenotyping differentiation during neurogenesis and рromotion of survival as differentiated so as undifferentiated neural cells. But the scenario of signal molecules expression in early embryonic stage is poorly understood. Therefore we examined expression of neurotrophic factors BDNF, NGF, GDNF, NT-3, NT-4/5 and CNTF in human brain from emryonic weeks 5-9 by DNA-RNA hybridization on nitrocellulose filter.
These study revealed that only BDNF, NT-3 and NT4/5 were expressed in detectable rate in these period. Other factors demonstrated no expression ore its mRNK rate was aut of sensitiveness of these method.
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Copyright (c) 2003 V. I. Tsymbaliuk, I. G. Vasilyeva, E. S. Galanta, N. G. Chopik, O. I. Tsyubko, N. P. Olexenko, T. N. Vaschulenko
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