Immune responses in malignant gliomas of brain: literature review
DOI:
https://doi.org/10.25305/unj.57560Keywords:
local immune responses, tumor-infiltrating lymphocytes and macrophages, life expectancyAbstract
Recent publications on the immune reactions that occur in malignant brain gliomas were analyzed. The difference of immune cells — lymphocytes and macrophages accumulation in tumor tissue was shown; data on phenotypic characteristics of tumor-infiltrating lymphocytes (TILs), their antitumor activity and reasons for their varying infiltration were given. Data on T-regulating lymphocytes in tissue with suppressor properties were presented.
The question about TILs importance for tumors growth and their prognostic significance was discusses. The opinion that TILs can both stimulate tumor growth and suppress it was expressed.
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