Cerebral vasospasm after subarachnoid hemorrhage. Molecular aspects of endothelial dysfunction: literature review

Yuriy Zozulya, L. Senko

Abstract


The pathogenesis of cerebral vasospasm (CV) after subarachnoid hemorrhage (SAН) is multifactoral. Severe CV after SAH is prolonged contraction that leads to cerebral ischemia or infarction. Although have been many studies on cerebral vasospasm after SAH, the optimal treatment CV has not yet been established. In this review we have attempt to discussed many factors have been implication in the pathogenesis CV and mechanisms of dysfunction vasocontriction/vasodilation during SAH–induced CV and to present the general situation in the field of CV after SAH treatment.


Keywords


cerebral vasospasm; subarachnoid hemorrhage; endothelial dysfunction; endothelin; nitric oxide donor NO; intrathecal

References


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