Functional magnetic-resonance imaging of the brain and its diagnostical importance: a literature review

Olga Chuvashova


Review of method and analytical analysis of scientific information about functional magnetic-resonance imaging in 1990—2000 years was resulted. Questions about fMRI, authenticity of obtain results, applied paradigms and regions of activation in sensorimotor cortex, language function, visual function and other cortical brain areas was considered. We examine several disoders of CNS, in which fMRI was used with diagnostical aim. We consider importance fMRI method in brain functions characteristics at focal lisions of CNS.


functional magnetic resonance imaging; sensorimotor; speech; visual cortex of the brain; intracranial tumors; gliomas; epilepsy; cerebral blood flow


Aizenstein H.J., Macdonald A.M., Stenger V.A. et al. Complementary Category Learn system indentified using event-related functional MRI //J.Cong. Neurosci. — 2000. — V.12, №6. — P.977—987.

Angioi-Duprez K., Braun M., Jonveaux T. et al. Exploration of visual memory by functional MRI //J. Fr. Ophtalmol. — 2000. — V.23, №1. — P.19—26.

Atlas W.A., Howard R.S.II, Maldjian J. et al. Functional magnetic resonance imaging of regional brain activity in patients with intracerebral gliomas: findings and implications for clinical management //Neurosurgery. — 1996. — V.38. — P.329—337.

Bandetini P.A., Wong. E.C., Hinks R. et al. Time course EPI of human brain function during task aktivation // Magn.Reson.Med. — 1992. —V.25. — P.390—397.

Bandettini P.A., Wong E.C., Jesmanowicz A. et al. Spin-echo and gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1,5 T // NMR Biomed. — 1994. — V.7. — P.12—20.

Bandetini P.A., Wong. E.C., Hinks R. et al. Time course EPI of human brain function during task aktivation // Magn.Reson.Med. — 1992. —V.25. — P.390—397.

Bandettini P.A., Wong E.C., Yoe E.A. et al. Functional dynamics of blood oxygenation level dependent contrast in the motor cortex // Proc.SMRM. — 1993. — P.1382—1391.

Baudendistel K., Schad L.R., Friedlinger M. et al. Postrocessing of functional MRI data of motor cortex stimulation measured with a standard 1,5 imager // Magn. Reson. Imaging. — 1995. — V.13, №5. — P.701—707.

Baumann S.B., Noll D.C., Kondziolka D.S. et al. Comparison of functional magnetic resonance imaging with position emission tomography and magnetoencephalography to edentify the motor cortex in a patient with an arteriovenous malformation // J.Image Guid.Surg. — 1995. — V.1 — P.191—197.

Belliveau J.W., Kennedy D.N., McKinstry R.C. et al. Functional mapping of the human visual cortex by magnetic resonance imaging // Science. — 1991. —V.254. — P.716—719.

Belliveau J.W., Rosen B.R., Kantor H.L. et al. Functional cerebral imaging by susceptibility-contrast NMR // Magn.Reson.Med. — 1990. — V.14. — P.538—546.

Berry I., Dmonet J-F., Warach S. et al. Activation of association auditory cortex demonstrated with functional MRI // Neuroimage. — 1995. — V.2. — P.215—219.

Binder J.R. Neuroanatomy of language processing studied with functional MRI // Clin. Neurosci. — 1997. — V.4. — P.87—94.

Binder J.R., Frost J.A., Hammeke T. et al. Human brain language areas identified by functional magnetic resonance imaging // J.Neurosci. — 1997. — V.17. — P.353—364.

Binder J.R., Rao S.M., Hammeke T.A. et al. Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging // Arch.Neurol. — 1995. — V.52. — P.593—601.

Binder J.R., Rao S.V., Hammeke T.A. et al. Functional magnetic resonance imaging of human auditory cortex // Ann.Neurol. — 1994. — V.35. — P.662—672.

Binder J.R., Swanson S.J., Hammeke T.A. et al. Determination of language dominance using functional MRI: a comparison with the Wada-test // Neurology. — 1996. — V.46. — P.978—987.

Blamire A.M. Ogawa S., Ugurbil K. et al. Mapping of the visual cortex by high-speed magnetic resonance imaging // Proc.Natl.Acad.Sci.USA. — 1992. —V.89. — P.11069.

Bucher S.F., Seelos K.C., Stehling M.K. et al. Technical apporoaches functional magnetic resonance imaging // Radiolige. — 1995. — V.35. —P.228—235.

Bucher S.F., Seelos K.S., Stehling M. et al. High resolution activation mapping of basal ganglia with functional magnetic resonance imaging // Neurology. — 1995. — V.45. — P.180—182.

Cao Y., D’Olhaberriague L., Vikingstod E.M. et al. Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis // Stroke. — 1998. — V.29, №1. — P.112—122.

Cao Y., Towle V.L., Levin D.N., Balter J.M. Functional mapping of human motor cortical activation with conventional MR imaging at 1,5 T // Magn.Reson.Imaging. — 1993. — V.3. — P.869—878.

Cettolo V., Frangesto M.P., Zuiani C. et al. Functional mapping of the motor and primary sensorial cortex using magnetic resonance tectiques. II Image analysis techniques // Radiol. Med. — 1996. — V.92, №5. — P.554—561.

Cohen J.D.,FormanS.D., Braver T.S. et al. Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI /Hum. Brain. Mapp. — 1994. — V.1. — P.293—304.

Connelly A., Jackson G.D., Frackowiak RSJ. et al. Functional mapping of activated human primary cortex with a clinical MR imaging system // Radiology. — 1993. — V.188. — P.125—130.

Cox R.W. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages [Abstract] // Proc. Society for Magnetic. Resonance. Soc. Magn. Reson. Med. — 1995. — P.834.

Cramer S.C., Moore C.J., Finklestein S.P., Rosen B.R. A pilot study of somatotopic mapping after cortical infarct // Stroke. — 2000. — V.31, №3. — P.668—671.

Cramer S.C., Nelles G., Benson R.R. et al. A functional MRI study of Subjects recovered from hemiparatic stroke // Stroke. — 1977. — V.28, №12. — P.18—27.

Cuenod C.A., Bookheimer S.Y., Hertz-Pannier L., et al. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment // Neurology. — 1995. — V.45. — P.1821—1832.

DavisK.D. The neural circuity of pain as explored with functional MRI //Neurol. Res. — 2000. — V.22, №3. — P.313—317.

Desmond J.E., Sum J.M., Wargner A.D. et al. Functional MRI measurement of language lateralization in Wada-tested patients // Brain. — 1995. — V.118. — P.1411—1420.

Dymarkowski S., Sunaert S., Van Oostende S., et al. Functional MRI of the brain localisation of eloquent cortex in focal brain lesion therapy // European Radiologi. — 1998. — V.8, №9. — P.1573—1580.

Engel S.A., Rumelhart D.E., Wander B.A. et al. fMRI of human visual cortex // Nature. — 1994. — V.369. — P.525.

Fahlbush R., Ganslandt O., Nimsky C. Intraoperative imaging with open magnetic resonance imaging and neuronavigation // Childs Nerv.Syst. — 2000. — V.16, №10—11. — P.829—831.

Fandino J., Kollias S.S., Wieser H.G. et al. Intraoperative validation of functional magnetic resonance imaging and cortical reorganization patterns in patients with brain tumor involving the primary motor cortex // J.Neurosurg. — 1999. — V.91, №2. — P.238—250.

Fellner C., Schaier J., Fellner F. et al. Functional MR imaging of the motor cortex in healthy volunteers and patients with brain tomours: qualitative and quantitative results // Rontgenpraxis. — 1999. —V.52, №1. — P.3—14.

Fisel C.R., Ackerman J.L., Buxton R.B. et al. MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology // Magn.Reson.Med. — 1991. —V.17. — P.336—342.

Frahm J., Merboldt K.D., Hsnicke W. Functional MRI of human brain activation at high spatial resolution // Magn. Reson. Med. — 1993. — V.29. — P.139—144.

Friedman L., Kenny J.T., Wise A.L. et al. Brain activation during silent world generation evaluated with functional MRI // Brain Lang. — 1998. — V.64, №2. — P.231—256.

Friston K.J., Jezzard P., Turner R. The analysis of functional MRI time-series // Hum. Brain. Mapping. — 1994. — V.1. — P.153—171.

Friston K.J., Williams S., Howard R. et al. Movement-related effects in fMRI time series // Magn.Reson.Med. — 1996. — V.35. — P.346—353.

Geyer S., Ledberg A., Schorman T. et al. Microstructure and function of the primary somatosensory cortex of man: an integrative study using cytoarchitectonic mapping and PET // Hum.Brain Mapping. — 1996. — V.3. — P.18.

Hajnal J.V., Myers R., Oatridge A. et al. Artifacts due to stimulus correlated motion in functional imaging of the brain // Magn.Reson.Med. — 1994. — V.31. — P.283—290.

Hammeke T.A., Yetkin F.Z., Mueller W.M. et al. Functional magnetic resonance imaging of somatosensory stimulation // Neurosurgery. — 1994. — V.35 — P.667—681.

Henning J., Speck O., Lцnneker T., Janz C. Fundamentals of functional magnetic resonance measurements // Padiologe. — 1995. — V.35. — P.221—229.

Hertz-Pannier L. Brain plasticity during development: physiological bases and functional MRI approach // J.Neuroradiol. — 1999. — V.26, №1. — P.66—74.

Hertz-Pannier L., Gaillard W.D., Mott W.D. et al. Noninvasive assessment of language clominance in children and adolescents with functional MRI: a preliminary study // Neurology. — 1997. — V.48, №4. — P.1003—1012.

Jack C.R., Thompson R.M., Kim Butts R. et al. Sensory motor cortex: correlation of presurgical mapping with functional MR imaging and invasive cortical mapping // Radiology. — 1994. — V.190. — P.85—92.

Kampe K.K., Jones R.A., Auer D.P. Frequency dependence of the functional MRI response after electrical median nerve stimulation // Hum.Brain.Mapp. — 2000. — V.9, №2. — P.106—114.

Kim S-G., Ugurbil K., Strick P.L. Activation of a cerebellar output nucleus during cognitive processing / Science. — 1994. — V.265. — P.949—951.

Kleinschmidt A., Merboldt K-D, Hsnicke W. et al. Correlation imaging of thalamocortical coupling in the primary visual pathway of the human brain // J.Cereb.Blood Flow.Metab. — 1994. — V.14. — P.952—957.

Kwong K.K. Functional magnetic resonance imaging with echo planar imaging // Magn.Reson.Q., — 1995. — V.11, №1. — P.1—20.

Kwong K.K., Belliveau J.W., Chesler D.A. et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation // Proc.Natl.Acad.Sci.USA. — 1992. —V.89. — P.5675—5679.

Le Bihan D., Karni A. Applications of magnetic resonance imaging to the study of human brain function // Curr.Opin.Neurobiol. — 1995. — V.5— P.231—237.

Lehericy S., Duffau H., Cornu P. et al. Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: comparison with intraoperative stimulation in patients with brain tumors // J.Neurosurg. —2000. — V.92, №4. — P.589—598.

Lehericy S., Marsault, Le Bihan D. Functional MRI: brain plasticity, brain disease and functional recovery // J.Neuroradiol. — 1999. — V.26, №1. — P75—81.

Leslie R.A., James M.F. Pharmacological magnetic resonance imaging: a new application for functional MRI //Trends Pharmacol. Sci. — 2000. — V.21, №8. — P.314—318.

Levy L.M., Henkin R.I., Hutter A. et al. Functional MRI of human olfaction //J. Comput. Assit. Tomogr. — 1997. — V.21, №6. — P.849—956.

Lobel E., Kleine J.F., Bihan D.L. et al. Functional MRI of galvanic vestibular stimulation // J.Neurophysiol. — 1998. — V.80, №5. — P.2699—2709.

Macdonell R.A., Jachson G.D., Curatalo J.M. et al. Motor cortex localization using functional MRI and transcranial magnetic stimulation // Neurology. — 1999. —V.53, №7. — P.1462—1467.

Makabe T., Edmister W.B., Jenkins B.G. et al. Brain structures of reading Japanese words with functional MRI // Nippon Rinsho. — 1997. — V.55, №7. — P.1699—1705.

Maldjian J., Atlas S.W., Howard R.S. et al. Functional magnatic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations befone surgical of endovascular therapy // Neurosurg. — 1996. — V.84. — P.477—483.

Matthews P.M., Clare S., Adcock J. Functional magnetic resonance imaging. Clinical applications and potential //J.Inherit. Metab. Disease. — 1999. — V.22, №4. — P.337—352.

Menon R.S.,LuknowshyD.C., Gati J.S. Mental chrohometry using latency — resolv“ed fuctional MRI // Proc. Natl. Acad. Sci.USA. — 1998. — V.95, №18. — P.10902—10907.

Mueller W.M., Yetkin F.Z., Hammeke T.A. et al. Functional magnetic resonance imaging mapping the motor cortex in patients with cerebral tumors //Neurosurgery. — 1996. — V.39. — P.515—521.

Nakada T., Fujii Y., Susuki K., Kwee I.L. “Musical brain” revealed by highfield (3 Tesla) functional MRI //Neuroreport. — 1998. — V.9, №11. — P.3853—3856.

Nimsky C., Ganslant O., Kober H. et al. Integration of functional magnetic resonance imaging supported by magnetoencephalography in functional neuronavigation // Neurosurgery. — 1999. — V.44, №6. — P.1249—1255.

Nitschke M.F., Melchert U.H., Hahn C. et al. Preoperative functional magnetic resonance imaging (fMRI) of the motor system in patients with tumors in the parietal lobe // Asta Neurochir. — 1998. — V.140, №12. — P.1223—1229.

Ogawa S., Lee T., Kay A., Tank D.W. Brain magnetic resonance imaging with constant dependent on blood oxygenation // Prog.Natl.Acad.Sci.USA. — 1990. — V.87. — P.9868—9872.

Ogawa S., Lee T.N., Nayak A. et al. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging of rodent brain mapping with magnetic resonance imaging // Magn.Reson.Med. — 1990. —V.14. — P.68—78.

Ogawa S., Melon S., Tank W. et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging // Biophys.J. — 1993. —V.64. — P.803—812.

Ogawa S.D., Tank D.W., Menon R.S. et al. Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping using MRJ // Proc.Natl.Acad.Sci.USA. — 1992. —V.89. — P.5951—5955.

Parke K., Hellmann T., Renger B. et al. Clinical applications of functional MRJ at 1,0 T: motor and language studies in healthy subjects and patiens // European Radiology. — 1999. — V.I , №2. — P. 211 — 220.

Porro C.A., Francescato M.P., Cettolo V. et al. Primary motor and sensory cortex activation during motor performance and motor imagery: a functional magnetic resonance imaging study // J.Neurosci. — 1996. — V.16. — P.7688—7693.

Rao S.M., Binder J.R., Bondetlini P.A. et al. Functional magnetic resonance imaging of complex human movements // Neurology. — 1993. — V.43. — P.2311—2318.

Rao S.M., Binder J.R., Hammeke T.A. et al. Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging // Neurology. — 1995. — V.45. — P.919—924.

Roberts T.P., Zusman E., Mc Dermott M. et al. Correlation of functional magnetic source imaging with intraoperative cortical stimulation in neurosurgical patients // J. Image Guid. Surg. — 1995. — V.1, №6. — P.339—347.

Rombouts Serge A.R.B., Barkhof F., Veltman D.J. et al Functional MRI imaging in Alzheimer’s Disease during memory encoding //AJNR. — 2000. — V.21, №10. — P.1869—1875.

Rossini P.M., Caltagirone C., Castriota-Scanderberg A. et al. Hand motor cortical area reorganization in stroke: a study with fMRJ, MEG and TCS maps // Neuroreport. — 1998. — V.22, №9. — P.2141—2146.

Roux F.E., Boulanouar K., Ibarrola D., Berry I. Practical role of fuctional MRI in neurosurgery //Neurochirurgie. — 2000. — V.46, №1. — P.11—22.

Poux F.E., Boulanouar K., Ranjeva J.P. et al. Usefulness of motor functional MRI Correlated to cortical mapping in Rolandic Low-grade astrocytomas // Acta Neurochir. — 1999. — V.141, №1. — P.71—79.

Roux F.E., RanjevaI.P., Boulanouar K. et al. Motor functional MRI for presurgical evaluation of cerebral tumors // Stereotact.Funct.Neurosurg. — 1997. — V.68, № 1—4. — P.106—111.

Sabatini U., Boulanouar K., Fabre N. et al. Cortical motor reorganization in akinetic patients with Parkinson’s disease: a functional MRI study //Brain. — 2000. — V.123, №2. — P.394—403.

Schneider W., Casey B.J., Noll D. Functional MRI mapping stimulus rate effects across visual processing stages // Hum.Brain Mapp. — 1994. — V.1 — P.117—133.

Schulder M., Maldjian J.A., Liu W.C. et al. Functional MRI image-guided surgery of intracranial tumors located in or near the sensorimotor cortex //J.Neurosurg. — 1998. — V.89, №3. — P.412—418.

Schulder M., Vega J., Nazza V. et al. Functional magnetic resonance imaging and radiosurgical dose planning //Stereotact. Funct. Neurosurg. — 1999. — V.73, №1—4. — P.38—44.

Shaywitz B.A., Pugh K.R., Constable R.T. et al. Localization semantic processing using functional magnetic resonance imaging // Hum. Brain Mapp. — 1995. — V.2. — P.149—158.

Shaywitz B.A., Shaywitz S.E., Pung K.R. et al. Sex differences in the functional organization of the brain for language // Nature. — 1995. — V.373. — P.607—609.

Shiino A., Morita Y., Ito R. et al. Functional MRI of the human brain responses to olfactory stimulation //No Shinkei Geka. — 1999. — V.27, №12. — P.1105—1100.

Takahashi C., Minowa K., Kaneko K. et al. Functional MRI of mastication // Riv.neuroradiol. — 1998. — V.11, №2. — P.145—148.

Tartoro A., Antonazzo R., De Matthaeis P. et al. Organizzazione delta corteccia somatosensoriale secondaria. Studio con risenanza magnetica funxzionalle // Rev.neuroradial. — 1999. — V.12, №4. — P.509—514.

Thompson R.M., Jack C.R., Butts K. et al. Imaging of cerebral activation at 1,5 T: optimizing technique for conventional hardware // Radiology. — 1994. — V.190. — P.873—877.

Tortora G., DiSalle F., Bali M. et al. fMRI study of silent word production. // Abstr.Loth European Congress of Radiolody. — ECR’97. — Viena, Austria, 1997. — P.725.

Turner R., Jazzard P., Wen H. et al. Functional mapping of the human visual cortex at 4 and 1,5 T using deoxygenation contrast EPI // Magn.Reson.Med. — 1993. —V.29. — P.277—279.

Tyszka J.M., Grafon S.T., Chew W. et al. Parceling of medial frontal motor areas during ideation and movement using functional magnetic resonance imaging at 1,5 tesla // Ann.Neurol. — 1994. — V.35. — P.746—749.

Witt T.C., Kondziolka D., Baumann S.B. et al. Preoperative cortical localization with functional MRI for use in stereotactic radiosurgery //Stereotact. Funct. Neurosurg. — 1996. — V.66, №1—3. — P.24—29.

Yamado H. Brain functional MRI of the visual cortex with echo planar imaging // Nippon Rinsho. — 1997. — V.55, №7. — P.1684—1687.

Yousry T.A., Schmid U.D., Jassy A.G. et al. Tomography of the cortical hand area: prospective study with functional MR imaging and invasive cortical mapping at surgery // Radiology. — 1995. — V.195. — P.23—29.

Yousry T.A., Schmid U.D., Jassoy A.G. et al. Tomography of the cortical motor hand area: prospective study with functional MR imaging and direct motor mapping at surgery // Radiology. — 1995. — V.195. — P.23—29.

Zeineh M.M., EngelsS.A., Bookheimer S.Y. Application of cortial unfolding techniques to functional MRI of the human hippocampal region //Neuroimage. — 2000. — V.11, №1. — P.668—683.

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