Low-dose linac-based stereotactic radiosurgery for skull base meningiomas

Authors

  • Irina Kruchok Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Olga Chuvashova Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Lyudmila Verbova Infratentorial Neuro-Oncology Department, Romodanov Neurosurgery Institute, Kiev, Ukraine
  • Andrey Gryazov Romodanov Neurosurgery Institute, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.50247

Keywords:

skull base meningiomas, stereotactic radiosurgery, linear accelerator

Abstract

Objective. To analyze the results of patients’ treatment skull base meningiomas, using linac-based low-dose (≤12.5 Gy) SRS, to estimate the efficacy of this method.

Materials and methods. SRS, using linear accelerator «Trilogy + BrainLab» was performed in 75 patients with skull base meningiomas (Karnofsky index ≥ 80). The target’s volume ranged from 1.21 до 20.9 см3, the marginal dose — from 11 to 12.5 Gy, the part of target that received the marginal dose, ranged from 70% to 100%. 61 patients were followed from 2 to 44 months (median, 11 months).

Results. The clinical status was unchanged in 96.7% of patients. After SRS, 47.6% patients presented with tumor size reduction; 50.8 % remained stable; in 98.4% — the control of tumor growth was achieved.

Conclusions. SRS − is effective method of treatment for skull base meningiomas, providing high rate of tumor control (98.4%) and ensuring safety of patient’s neurological status (Karnofsky index ≥ 80). SRS with using lower marginal doses (≤12.5 Gy), allows to reduce frequency and severity of both transient and permanent neuropathy (in 96.7% cases).

Author Biographies

Irina Kruchok, Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev

Відділ нейрорадіології та радіонейрохірургїі

Olga Chuvashova, Department of Neuroradiology and Radioneurosurgery, Romodanov Neurosurgery Institute, Kiev

Відділ нейрорадіології та радіонейрохірургїі

Lyudmila Verbova, Infratentorial Neuro-Oncology Department, Romodanov Neurosurgery Institute, Kiev

Відділення субтенторіальної нейроонкології

Andrey Gryazov, Romodanov Neurosurgery Institute, Kiev

Department of Neuroradiology and Radioneurosurgery

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Published

2015-09-16

How to Cite

Kruchok, I., Chuvashova, O., Verbova, L., & Gryazov, A. (2015). Low-dose linac-based stereotactic radiosurgery for skull base meningiomas. Ukrainian Neurosurgical Journal, (3), 54–57. https://doi.org/10.25305/unj.50247

Issue

No. 3 (2015)

Section

Original articles

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Copyright (c) 2015 Irina Kruchok, Olga Chuvashova, Lyudmila Verbova, Andrey Gryazov

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