Peculiarities of immune disordess in remote period of experimental mild craniocerebral injuries against the background of chronic effects of small-dose ionizing radiation
Keywords:
mild traumatic brain injury, ionizing radiation, immunology, mitogens, blast transformation of lymphocytesAbstract
Immune disorders in the late period of craniocerebral injuries against the background of chronic effect of small doses of ionizing radiation have been studied in vitro. The experiments were carried out on white rats who were divided into 4 groups. The object of the investigation was the blood and the spleen. It has been found out that during development of traumatic diseases of brain against the background of internal radiation of the animal organism with small doses of radiation there develop significant shifts in the function activity of lymphocytes, namely: proliferative activity of B-lymphocytes is inhibited, immunoregulatory function of suppressor cells is impaired, endogenic activation of lymphocytes increases. At the same time changes in the proliferative activity of T-lymphocytes were insignificant in all groups of the studied animals. The revealed changes were more marked in the spleen than in the blood, it testifying to the prevalent lesion of immune organs. The character of these changes is mainly caused by disturbances induced by the action of ionizing radiation.
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