Clinical and morphological estimation of radiation therapy efficiency in adults with medulloblastoma
DOI:
https://doi.org/10.25305/unj.45301Keywords:
medulloblastoma, histological features, radiation therapy, radiation pathomorphosisAbstract
Introduction. Concerning the relevance of estimation of radiation therapy (RT) efficiency in adults with cerebellar medulloblastoma, histological features of therapeutic pathomorphosis in tumors tissue after RT studied.
Materials and methods. Comparative aspects of medulloblastomas histological structure investigated in 24 adult patients before and after RT using biopsy material at first and repeated operations.
Results. Based on assessment of cell-tissue changes severity in medulloblastoma in adults after RT we installed individual differences of sensitivity to RT in most of them.
Conclusions. Standard RT course in adults with medulloblastoma after surgery induces in tissue of most “treated” tumors cytotoxic and cytodestructive effect that correlates with disease-free period prolongation.
References
Louis D. WHO Classification Of Tumours Of The Central Nervous System. Geneva, Switzerland: Distributed by WHO Press, World Health Organization; 2007.
Badmayev KN, Smirnov RV. Radionuklidnaya diagnostika i luchevaya terapiya zabolevaniy nervnoy sistemy [Nuclear medicine and radiation therapy of diseases of the nervous system]. Moscow: Meditsina; 1982. Russian.
Brodskiy YuS, Orlov YuA, Brodskaya IA. Kombinirovannoye lecheniye detey pri medulloblastomakh mozzhechka [Combined treatment of children with medulloblastoma of the cerebellum]. Klin. onkologiya. 1991;11:56–60. Russian.
Riffaud L, Saikali S, Leray E et al. Survival and prognostic factors in a series of adults with medulloblastomas. Journal of Neurosurgery. 2009;111(3):478-487. CrossRef
Ciccarino P, Rotilio A, Rossetto M et al. Multifocal presentation of medulloblastoma in adulthood. Journal of Neuro-Oncology. 2011;107(2):233-237. CrossRef
Padovani L, André N, Carrie C, Muracciole X. Le médulloblastome de l’enfant et de l’adulte : quelle différence ?. Cancer/Radiothérapie. 2009;13(6-7):530-535. CrossRef
Abacioglu U, Uzel O, Sengoz M, Turkan S, Ober A. Medulloblastoma in adults: treatment results and prognostic factors. International Journal of Radiation Oncology*Biology*Physics. 2002;54(3):855-860. CrossRef
Curran E, Sainani K, Le G, Propp J, Fisher P. Gender affects survival for medulloblastoma only in older children and adults: A study from the surveillance epidemiology and end results registry. Pediatric Blood & Cancer. 2009;52(1):60-64. CrossRef
Krayevskiy N, Smol'yannikov A, Sarkisov D, ed. Patologoanatomicheskaya Diagnostika Opukholey Cheloveka [Pathologic diagnosis of human tumors]. 4th ed. Moscow: Meditsina; 1993. Russian.
Galakhin KA, Yugrinov YuG, Kurik YeG, Melnik NN, Koshubarova MV, Polyakova TV, Bazdyrev VV. Khimioterapevticheskiy patomorfoz zlokachestvennykh opukholey. Ukr. khímíoterapevt. zhurn. 2000;4:8-12. Russian.
Galakhin K, Kurik Ye, Kovalchuk E, Skoroda L, Troitskaya I, Melnik N, Bazdyrev V, Polyakova T, Bashinskiy S, Groysman D. Zakonomernosti lechebnogo patomorfoza zlokachestvennykh opukholey. In: Abstracts Book of the Х Congress of Oncologists of Ukraine; 2001 October 10-12; Yalta, Ukraine. Kiev; 2001:296-297. Russian
Semenova V. Lechebnyy patomorfoz gliom. In: Zozulya Yu, ed. Gliomy Golovnogo Mozga. Kiev: Ekspress-Poligraf; 2007:569–597. Russian.
Brodskaya I, Orlov Yu. Kletochnaya differentsirovka medulloblastomy mozzhechka u detey. In: Respublikanskiy sbornik nauchnykh trudov: Aktualnyye voprosy neyrokhirurgii detskogo vozrasta. Leningrad: LNKHI; 1990:67–70. Russian.
Chernenko O. Morfolohichni osoblyvosti meduloblastom mozochka [dissertation]. Kiev (Ukraine): Bogomolets National Medical University; 2008. Ukrainian.
Wechsler-Reya R, Scott M. The developmental biology of brain tumors. Annu Rev Neurosci. 2001;24(1):385-428. CrossRef
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