Chemoresistance of brain glioma as a result of their genotype
Keywords:
glioma, chemoresistance, glutathione, P-glycoprotein, MDR1Abstract
The effectiveness of malignant brain tumors chemotherapy on the base of determination of tumor’s genotype (glutathion S-tranferases theta GST-Т and mu GST-М) and phenotype (glutathion S-tranferase activity) was investigated. No correlation between malignant grade of brain tumors and expression level of examined genes in them has been found. Our data indicate the need of further investigation of this problem and of the detail accounting of all mechanisms of tumor cell resistance.
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Copyright (c) 2004 I. G. Vasilyeva, A. Ya. Glavatskiy, N. G. Chopick, N. P. Olexenko, O. I. Tsyubko, E. S. Galanta
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