Epidemiology, clinical and morphological analysis of diffuse astrocytic tumors based on data of citizens of Kharkiv region operated in neurosurgical departments of Kharkiv (2000–2015)
DOI:
https://doi.org/10.25305/unj.140720Keywords:
epidemiology of the CNS tumors, glioblastoma incidence rate, diffuse gliomas, diffuse astrocytic tumorsAbstract
Objective. To clarify the place of the diffuse astrocytic tumors in primary CNS tumor morbidity in Kharkiv region from 2000 to 2015.
Materials and methods. The research is based on 1920 case histories of patients with tumors of the central nervous system and their biopsies in the period from 2000 to 2015 years. Sex, age, tumor location, histology, and structure were analyzed. The statistical data was processed with Microsoft Excel 2010. Methods of mathematical statistics were used.
Results. Diffuse gliomas accounted for 46 % of all primary CNS tumors, 58 % of relapsed CNS tumors, and took the 1st place in the mortality rate from CNS tumors in Kharkiv region. 70.5 % of glioblastomas relapsed within the 1st year after surgery. 43.69 % of primary glioblastomas had intratumoral cysts.
Conclusion. 1. The incidence rate for glioma was higher in Kharkiv region (22.3 % from general CNS tumor incidence rate and 26 % from primary CNS tumor incidence rate) in comparison to WHO and CBTRUS data (12–15 % and 14.9 %, respectively). 2. Intratumoral cysts were found more commonly in glioblastomas than in other diffuse astrocytic tumors (43.69 % versus 33.47 %; Pearson’s chi-squared test =6.703; p < 0.01). 3. The most recurrent cases were represented by diffuse gliomas (58 %). 4. 70.5 % of glioblastomas relapsed within a year after surgery. 5. Glioblastoma was the most common cause of mortality in neurosurgical departments among all primary CNS tumors.
References
1. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016 Jun;131(6):803-20. [CrossRef] [PubMed]
2. Data from Kharkiv regional cancer registry (2000-2015). An official request from Kharkiv Medical Academy of Postgraduate Education 28.08.2018. Available upon personal request.
3. Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Neuro Oncol. 2017 Nov 6;19(suppl_5):v1-v88. [CrossRef] [PubMed] [PubMed Central]
4. Cancer in Ukraine. Incidence, mortality, activities of oncological service Bulletin of National Cancer Registry of Ukraine vol.3-18 [Internet]. Kyiv: National Cancer Institute of Ukraine; 2018. [cited 2018 August 13]. Available from: http://www.ncru.inf.ua/publications/
5. Astrocytic tumours. In: Louis DN, Ohgaki H, Wiestler OD, CaveneeWK, editors. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press; 2007. p. 13-53.
6. Life expectancy at birth. The population of Ukraine [Internet]. Kyiv: State Statistics Service of Ukraine; 2018. [cited 2018 August 13]. Ukrainian. Available from: http://www.ukrstat.gov.ua/operativ/operativ2007/ds/nas_rik/nas_u/nas_rik_u.html
7. Stockhammer G, Obwegeser A, Kostron H, Schumacher P, Muigg A, Felber S, Maier H, Slavc I, Gunsilius E, Gastl G. Vascular endothelial growth factor (VEGF) is elevated in brain tumor cysts and correlates with tumor progression. Acta Neuropathol. 2000 Jul;100(1):101-5. [CrossRef] [PubMed]
8. Choi SJ, Hwang HY, Kim NR, Lee S-W, Kim JH, Choi H-Y, Kim H-S. The Radiologic Features of Cystic versus Noncystic Glioblastoma Multiforme as Significant Prognostic Factors. Journal of the Korean Society of Radiology. 2010;63(4):299. [CrossRef]
9. Kaur G, Bloch O, Jian BJ, Kaur R, Sughrue ME, Aghi MK, McDermott MW, Berger MS, Chang SM, Parsa AT. A critical evaluation of cystic features in primary glioblastoma as a prognostic factor for survival. J Neurosurg. 2011 Oct;115(4):754-9. [CrossRef] [PubMed]
10. Rajabpour MV, Yahyazadeh H, Beheshi M. Prognostic factors and survival of glioblastoma multiform in iranian patients. International Journal of Cancer Management. 2017;10(4):1–7. [CrossRef]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Taisia Chertenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.
