Seizure in nontraumatic subarachnoid hemorrhage

Eugenia I. Tsoma

Abstract


Seizures are quite common in aneurysmal subarachnoid hemorrhage (SAH). The prevalence is from 6 to 24% in all non-traumatic subarachnoid hemorrhages. They can be early – develop within first two weeks, or late seizures, that can become symptomatic post-stroke epilepsy. Quite often (13-24%) seizure can be the first clinical symptom of SAH, concomitant or isolated from thunderclap headache. Other factors, such as low Hunt-Hess, WFNS, GCS in onset, intracerebral hematoma, obstructive hydrocephalus, symptomatic vasospasm are associated with worse prognosis. But the influence of seizure for patient’s outcome is open to debate and is the least studied issue. Accordingly to this, there are no clear recommendations or guidelines for anticonvulsive therapy for primary and secondary prevention and improvement of the prognosis for a patient with SAH. The aim of this article is to review the literature and research data of recent years in order to find out the place of seizures in subarachnoid hemorrhage.


Keywords


subarachnoid hemorrhage; seizure; succul anevrysm; Glasgow Coma Scale; Hunt-Hess Scale; the World Federation of Neurological Surgeons Scale; Fisher Scale

References


1. Koubeissi MZ, Alshekhlee A, Mehndiratta P, editors. Seizures in Cerebrovascular Disorders. Springer New York; 2015. [CrossRef]

2. van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001 Feb;124(Pt 2):249-78. [CrossRef] [PubMed]

3. O’Connor KL, Westover MB, Phillips MT, Iftimia NA, Buckley DA, Ogilvy CS,Shafi MM, Rosenthal ES. High risk for seizures following subarachnoid hemorrhage regardless of referral bias. Neurocrit Care. 2014 Dec;21(3):476-82. [CrossRef] [PubMed] [PubMed Central]

4. Choi KS, Chun HJ, Yi HJ, Ko Y, Kim YS, Kim JM. Seizures and Epilepsy following Aneurysmal Subarachnoid Hemorrhage : Incidence and Risk Factors. J Korean Neurosurg Soc. 2009 Aug;46(2):93-8. [CrossRef] [PubMed] [PubMed Central]

5. Pinto AN, Canhao P, Ferro JM. Seizures at the onset of subarachnoid haemorrhage. J Neurol. 1996 Feb;243(2):161-4. [CrossRef] [PubMed]

6. Dewan MC, Mocco J. Current practice regarding seizure prophylaxis in aneurysmal subarachnoid hemorrhage across academic centers. J Neurointerv Surg.2015 Feb;7(2):146-9. [CrossRef] [PubMed]

7. Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl JMed. 2006 Jan 26;354(4):387-96. Review. [CrossRef] [PubMed]

8. van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001 Feb;124(Pt 2):249-78. Review. [CrossRef] [PubMed]

9. Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P;International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group.International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding,subgroups, and aneurysm occlusion. Lancet. 2005 Sep 3-9;366(9488):809-17. [CrossRef] [PubMed]

10. Adelцw C, Andersson T, Ahlbom A, Tomson T. Hospitalization for psychiatricdisorders before and after onset of unprovoked seizures/epilepsy. Neurology. 2012 Feb 7;78(6):396-401. [CrossRef] [PubMed]

11. Allen BB, Forgacs PB, Fakhar MA, Wu X, Gerber LM, Boddu S, Murthy SB, Stieg PE, Mangat HS. Association of Seizure Occurrence with Aneurysm Treatment Modality in Aneurysmal Subarachnoid Hemorrhage Patients. Neurocrit Care. 2018 Feb 26. [CrossRef] [PubMed]

12. Pegoli M, Mandrekar J, Rabinstein AA, Lanzino G. Predictors of excellent functional outcome in aneurysmal subarachnoid hemorrhage. J Neurosurg. 2015 Feb;122(2):414-8. [CrossRef] [PubMed]

13. Kondziella D, Friberg CK, Wellwood I, Reiffurth C, Fabricius M, Dreier JP. Continuous EEG monitoring in aneurysmal subarachnoid hemorrhage: a systematic review. Neurocrit Care. 2015 Jun;22(3):450-61. Review. [CrossRef] [PubMed]

14. Dhakar MB, Hirsch LJ. Continuous EEG Monitoring for Status Epilepticus. Status Epilepticus. Springer International Publishing; 2017 Nov 9;283–98. [CrossRef]

15. Lindgren C, Nordh E, Naredi S, Olivecrona M. Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation. Neurocrit Care. 2012 Dec;17(3):367-73. [CrossRef] [PubMed]

16. Sutter R, Semmlack S, Kaplan PW. Nonconvulsive status epilepticus in adults - insights into the invisible. Nat Rev Neurol. 2016 May;12(5):281-93. Review. [CrossRef] [PubMed]

17. Maciel CB, Gilmore EJ. Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes. J Clin Neurophysiol. 2016 Jun;33(3):183-95. Review. [CrossRef] [PubMed]

18. LaRoche SM, Haider HA. The Management of Nonconvulsive Status Epilepticus in Adults. Status Epilepticus. Springer International Publishing; 2017 Nov 9;299–311. [CrossRef]

19. Crepeau AZ, Kerrigan JF, Gerber P, Parikh G, Jahnke H, Nakaji P, Little A,Chapman KE. Rhythmical and periodic EEG patterns do not predict short-termoutcome in critically ill patients with subarachnoid hemorrhage. J ClinNeurophysiol. 2013 Jun;30(3):247-54. [CrossRef] [PubMed]

20. De Marchis GM, Pugin D, Lantigua H, Zammit C, Tadi P, Schmidt JM, Falo MC,Agarwal S, Mayer SA, Claassen J. Tonic-clonic activity at subarachnoid hemorrhage onset: impact on complications and outcome. PLoS One. 2013 Aug 12;8(8):e71405. [CrossRef] [PubMed] [PubMed Central]

21. Schuss P, Hadjiathanasiou A, Borger V, Wispel C, Vatter H, Gьresir E. Poor-Grade Aneurysmal Subarachnoid Hemorrhage: Factors Influencing Functional Outcome--A Single-Center Series. World Neurosurg. 2016 Jan;85:125-9. [CrossRef] [PubMed]

22. Ohman J. Hypertension as a risk factor for epilepsy after aneurysmal subarachnoid hemorrhage and surgery. Neurosurgery. 1990 Oct;27(4):578-81. [PubMed]

23. Rivero Rodrнguez D, Scherle Matamoros C, Cъe LF, Miranda Hernбndez JL, Pernas Sбnchez Y, Pйrez Nellar J. Predictor’s of Mortality in Patients with AneurysmalSubarachnoid Haemorrhage and Reebleding. Neurol Res Int. 2015;2015:545407. [CrossRef] [PubMed] [PubMed Central]

24. Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl J Med. 2006 Jan 26;354(4):387-96. Review. [CrossRef] [PubMed]

25. Fung C, Balmer M, Murek M, Z’Graggen WJ, Abu-Isa J, Ozdoba C, Haenggi M, Jakob SM, Raabe A, Beck J. Impact of early-onset seizures on grading and outcome in patients with subarachnoid hemorrhage. J Neurosurg. 2015 Feb;122(2):408-13. [CrossRef] [PubMed]

26. Butzkueven H, Evans AH, Pitman A, Leopold C, Jolley DJ, Kaye AH, Kilpatrick CJ, Davis SM. Onset seizures independently predict poor outcome after subarachnoid hemorrhage. Neurology. 2000 Nov 14;55(9):1315-20. [CrossRef] [PubMed]

27. Feigin VL, Rinkel GJ, Lawes CM, Algra A, Bennett DA, van Gijn J, Anderson CS. Risk factors for subarachnoid hemorrhage: an updated systematic review ofepidemiological studies. Stroke. 2005 Dec;36(12):2773-80. Review. [CrossRef] [PubMed]

28. Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, HigashidaRT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P;American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association.Stroke. 2012 Jun;43(6):1711-37. [CrossRef] [PubMed]

29. Congress of Neurological Surgeons/American Association of Neurological Surgeons Joint Section Chairmen. Neurosurgery. Oxford University Press (OUP); 2002 Jan;50(1):35. [CrossRef]

30. Marigold R, Gьnther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database Syst Rev. 2013 Jun5;(6):CD008710. Review. [CrossRef] [PubMed]

31. Yi Chou SH. Outcomes after Early Anticonvulsant Discontinuation in Aneurysmal Subarachnoid Hemorrhage. Journal of Vascular Medicine & Surgery. OMICS Publishing Group; 2015;03(01). [CrossRef]

32. Kim DW, Kim TE, Ji M, Chun YI. Safety, Tolerability, and Pharmacokinetics of Fosphenytoin Loading in Patients With Subarachnoid Hemorrhage. Clin Neuropharmacol. 2015 Nov-Dec;38(6):248-51. [CrossRef] [PubMed]

33. Mink S, Muroi C, Seule M, Bjeljac M, Keller E. Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 2011 Oct;113(8):644-8. [CrossRef] [PubMed]

34. Baker CJ, Prestigiacomo CJ, Solomon RA. Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms. Neurosurgery. 1995 Nov;37(5):863-70; discussion 870-1. [CrossRef] [PubMed]

35. Shah D, Husain AM. Utility of levetiracetam in patients with subarachnoid hemorrhage. Seizure. 2009 Dec;18(10):676-9.[CrossRef] [PubMed]

36. Starke RM, Connolly ES Jr; Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management ofSubarachnoid Hemorrhage. Rebleeding after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2011 Sep;15(2):241-6. Review. [CrossRef] [PubMed]

37. Yerram S, Katyal N, Premkumar K, Nattanmai P, Newey CR. Seizure prophylaxis in the neuroscience intensive care unit. J Intensive Care. 2018 Mar 5;6:17. eCollection 2018. Review. [CrossRef] [PubMed] [PubMed Central]

38. Mahmoud SH, Buxton J. Seizures and Choice of Antiepileptic Drugs Following Subarachnoid Hemorrhage: A Review. Can J Neurol Sci. 2017 Nov;44(6):643-653. [CrossRef] [PubMed]

39. Jaja BNR, Schweizer TA, Claassen J, Le Roux P, Mayer SA, Macdonald RL; SAHIT Collaborators. The SAFARI Score to Assess the Risk of Convulsive Seizure during Admission for Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2017 Jun 27 [Epub ahead of print] [CrossRef] [PubMed]

40. Datar S, Rabinstein AA. Postinterventional critical care management of aneurysmal subarachnoid hemorrhage. Curr Opin Crit Care. 2017 Apr;23(2):87-93. [CrossRef] [PubMed]

41. Boccardi E, Cenzato M, Curto F , Motto C. Diagnosis and Therapy in the Acute Phase of Hemorrhagic Stroke: Latest Developments. Hemorrhagic Stroke. 2017:1-97. [CrossRef]

42. Pritchard JM, Hopp JL. Epidemiology of Seizures in Critically Ill Adults. Continuous EEG Monitoring. 2017:13-27. [CrossRef]

43. De Marchis GM, Pugin D, Meyers E, Velasquez A, Suwatcharangkoon S, Park S, Falo MC, Agarwal S, Mayer S, Schmidt JM, Connolly ES, Claassen J. Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome.Neurology. 2016 Jan 19;86(3):253-60. [CrossRef] [PubMed] [PubMed Central]


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DOI: https://doi.org/10.25305/unj.130573

Copyright (c) 2018 Eugenia I. Tsoma

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