Antidyskinetic effect of stereotactic interventions in the ventrointermedial nucleus of the thalamus in patients with Parkinson’s disease
DOI:
https://doi.org/10.25305/unj.127577Keywords:
Parkinson’s disease, levodopa-induced dyskinesia, thalamotomyAbstract
Objective. To investigate the peculiarities of the antidyskinetic effect of stereotactic interventions in ventrointermedial (Vim) thalamic nucleus in patients with Parkinson’s disease (PD).
Materials and methods. Ventrointermedial thalamotomy (Vim-thalamotomy) for resistant tremor was performed in 10 patients with initial levodopa-induced dyskinesias (LIDs), which were considered as the secondary symptoms and were not taken into account when selecting the nucleus target (group 1). The study also includes 8 patients with LIDs developed due to disease progression after the Vim-thalamotomy performed earlier (group 2).
Results. In group 1 after Vim-thalamotomy, 9 out of 10 patients had LIDs control in the contralateral limbs. A similar clinical observation was found in all 8 patients in group 2: while LIDs manifested on the ipsilateral side of the previously performed Vim-thalamotomy, they did not develop on the contralateral side. Such apparent antidyskinetic effects of our Vim-thalamotomіes contradict contemporary knowledge about the anatomical and pathophysiological features of LIDs.
Conclusions. The control of LIDs after Vim-thalamotomy in patients with PD may indicate the afferent pallidal projections of ventrolateral thalamus involvement into the lesion. Combined anti-tremor and antidyskinetic effects are possible with the localization of the stereotactic target 3 mm behind the midcommissural point and/or with the diagonal trajectory of the electrode with an uninsulated tip of 4 mm in length. Appropriate stereotactic coordinates can be recommended for the operation of choice for patients with PD with tremor — LID symptom complex.
References
1. Krack P, Dostrovsky J, Ilinsky I, Kultas-Ilinsky K, Lenz F, Lozano A, Vitek J.Surgery of the motor thalamus: problems with the present nomenclatures. Mov Disord. 2002;17 Suppl 3:S2-8. Review. [CrossRef] [PubMed]
2. Ohye C, Hirai T, Miyazaki M, Shibazaki T, Nakajima H. Vim thalamotomy for the treatment of various kinds of tremor. Appl Neurophysiol. 1982;45(3):275-80. [CrossRef] [PubMed]
3. Jankovic J, Cardoso F, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery.1995 Oct;37(4):680-6; discussion 686-7. [CrossRef] [PubMed]
4. Marras C, Lang A, Krahn M, Tomlinson G, Naglie G; Parkinson Study Group. Quality of life in early Parkinson’s disease: impact of dyskinesias and motor fluctuations. Mov Disord. 2004 Jan;19(1):22-8. [CrossRef] [PubMed]
5. Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov. Disord. 2001;16:448-58. [CrossRef] [PubMed]
6. Obeso JA, Rodriguez-Oroz MC, Rodriguez M, DeLong MR, Olanow CW. Pathophysiology of levodopa-induced dyskinesias in Parkinson’s disease: problems with the current model. Ann Neurol. 2000 Apr;47(4 Suppl 1):S22-32; discussion S32-4. Review. [PubMed]
7. Cardoso F, Jankovic J, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for dystonia and hemiballismus. Neurosurgery. 1995 Mar;36(3):501-7;discussion 507-8. Review. [CrossRef] [PubMed]
8. Ohye C, Maeda T, Narabayashi H. Physiologically defined VIM nucleus. Its special reference to control of tremor. Appl Neurophysiol.1976-1977;39 (3-4):285-95. [CrossRef] [PubMed]
9. Diederich N, Goetz CG, Stebbins GT, Klawans HL, Nittner K, Koulosakis A, Sanker P, Sturm V. Blinded evaluation confirms long-term asymmetric effect of unilateral thalamotomy or subthalamotomy on tremor in Parkinson’s disease.Neurology. 1992 Jul;42(7):1311-4. [CrossRef] [PubMed]
10. Nagaseki Y, Shibazaki T, Hirai T, Kawashima Y, Hirato M, Wada H, Miyazaki M, Ohye C. Long-term follow-up results of selective VIM-thalamotomy. J Neurosurg. 1986 Sep;65(3):296-302. [CrossRef] [PubMed]
11. Benabid AL, Pollak P, Gao D, Hoffmann D, Limousin P, Gay E, Payen I, Benazzouz A. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg. 1996 Feb;84(2):203-14. [CrossRef] [PubMed]
12. Limousin P, Speelman JD, Gielen F, Janssens M. Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry. 1999 Mar;66(3):289-96. [CrossRef] [PubMed] [PubMed Central]
13. Tasker RR, Munz M, Junn FS, Kiss ZH, Davis K, Dostrovsky JO, Lozano AM. Deep brain stimulation and thalamotomy for tremor compared. Acta Neurochir Suppl.1997;68:49-53. [CrossRef] [PubMed]
14. Caparros-Lefebvre D, Blond S, Vermersch P, Pйcheux N, Guieu JD, Petit H. Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1993 Mar;56(3):268-73. [CrossRef] [PubMed] [PubMed Central]
15. Fox SH, Katzenschlager R, Lim SY, Ravina B, Seppi K, Coelho M, Poewe W, Rascol O, Goetz CG, Sampaio C. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson’s disease. Mov Disord. 2011 Oct;26 Suppl 3:S2-41. [CrossRef] [PubMed]
16. Guridi J, Obeso JA, Rodriguez-Oroz MC, Lozano AA, Manrique M. L-dopa-induced dyskinesia and stereotactic surgery for Parkinson’s disease. Neurosurgery. 2008 Feb;62(2):311-23; discussion 323-5. [CrossRef] [PubMed]
17. Brodkey JA, Tasker RR, Hamani C, McAndrews MP, Dostrovsky JO, Lozano AM. Tremor cells in the human thalamus: differences among neurological disorders. J Neurosurg. 2004 Jul;101(1):43-7. [CrossRef] [PubMed]
18. Narabayashi H, Yokochi F, Nakajima Y. Levodopa-induced dyskinesia and thalamotomy. J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):831-9. [CrossRef] [PubMed] [PubMed Central]
19. Page RD, Sambrook MA, Crossman AR. Thalamotomy for the alleviation of levodopa-induced dyskinesia: experimental studies in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated parkinsonian monkey. Neuroscience. 1993 Jul;55(1):147-65. [CrossRef] [PubMed]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Vitaliy I. Tsymbaliuk, Andrii O. Popov
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ukrainian Neurosurgical Journal abides by the CREATIVE COMMONS copyright rights and permissions for open access journals.
Authors, who are published in this Journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the Journal under the terms of Creative Commons Attribution License, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this Journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form of which it has been published by the Journal (for example, to upload the work to the online storage of the Journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this Journal is included.
