The surgical treatment improving at Lennox–Gastaut syndrome

Authors

  • A. O. Laponogov Romodanov Neurosurgery Institute, Kiev, Ukraine
  • V. I. Tsymbalyuk Romodanov Neurosurgery Institute, Kiev, Ukraine
  • K. R. Kostyuk Romodanov Neurosurgery Institute, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.112335

Keywords:

синдром Леннокса–Гасто, епілепсія, стереотаксичні операції, двобічна кріоамигдалектомія.

Abstract

The modern sights of Lennox–Gastaut syndrome management are given. The surgical methods, used in Lennox–Gastaut syndrome treatment are described. The results of one-stage bilateral stereotactic cryoamygdalectomy application in 8 children with Lennox–Gastaut syndrome are presented. In five cases the syndrome transformed from West syndrome. Most children had birth hypoxia, their seizures were resistance to antiepileptic treatment. In postoperative period (from 3 months to 4 years) one patient became seizure-free, other five children demonstrated seizure frequency reduction. In 2 cases the seizure frequency did not change. There were no surgical complications. The safety and efficacy of one-stage stereotactic bilateral amygdale complex ablation in children with Lennox–Gastaut syndrome were established.

References

Евтушенко С.К., Омельяненко А.А. Клиническая энцефалография у детей. — Донецк: Донеччина, 2005. — 260 с.

Петрухин А.С. Эпилептология детского возраста. — М.: Медицина, 2000. — 624 с.

Buoni S., Mariottini A., Pieri S. et al. Vagus nerve stimulation for drug-resistant epilepsy in children and young adults // Brain Dev. — 2004. — V.26, N3. — P.158–163.

Casazza M., Avanzini G., Ferroli P. et al. Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern // Seizure. — 2006. — V.15, N.3. — P.198–207.

Cukiert A., Burattini J.A., Mariani P.P. et al. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennoх–Gastaut and Lennox-like syndromes // Epilepsia. — 2006. — V.47, N2. — P.371–374.

Dulac O., N’Gueyn T. Lennox-Gastaut syndrome // Epilepsia. — 1993. — V.34, N7. — P.7–17.

Eder H.G., Feichtinger M., Pieper T. et al. Gamma knife radiosurgery for callosotomy in children with drug-resistant epilepsy // Childs Nerv. Syst. — 2006. — V.22, N8. — P.1012–1017.

Frost M., Gates J., Helmers S.L. et al. Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome // Epilepsia. — 2001. — V.42, N9. — P.1148–1152.

Gastaut H., Bughton R., Roger J., Tassinari C.A. Generalised convulsive seizures without local onset // Handbook Clinical Neurology: V.15. The Epilepsies / Ed. P.J. Vinken, G.W. Bruyn. — Amsterdam: Elsevier, 1974. — P.107–129.

Heiskala H. Community-based study of Lennox-Gastaut syndrome // Epilepsia. — 1997. — V.38, N.5. — P.526–531.

Hosain S., Nikalov B., Harden C. et al. Vagus nerve stimulation treatment for Lennox-Gastaut syndrome // J. Child Neurol. — 2000. — V.15, N8. — P.509–512.

Karceski S. Vagus nerve stimulation and Lennox–Gastaut syndrome: a review of the literature and data from the VNS patient registry // CNS Spectr. — 2001. — V.6, N9. — P.766–770.

Liu S., An N., Yang H. et al. Pediatric intractable epilepsy syndromes: reason for early surgical intervention // Brain Dev. — 2007. — V.29, N2. — P.69–78.

Nei M., O’Connor M., Liporace J., Sperling M.R. Refractory generalized seizures: response to corpus callosotomy and vagal nerve stimulation // Epilepsia. — 2006. — V.47, N1. — P.115–122.

Patil A.A., Andrews R.V., Johnson M., Rodriguez-Sierra J.F. Is epilepsy surgery on both hemispheres effective? // Stereotact. Funct. Neurosurg. — 2004. — V.82, N5–6. — P.214–221.

Roger J., Dravet C., Bureau M. The Lennox–Gastaut syndrome // Cleveland Clin. J. Med. — 1989. — Suppl.56. — P.172–180.

Rychlicki F., Zamponi N., Trignani R. et al. Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients // Seizure. — 2006. — V.15, N7. — P.483–490.

Trevathan E. Infantile spasms and Lennox-Gastaut syndrome // J. Child Neurol. — 2002. — V.17, suppl.2. — P.9–22.

Trevathan E., Murphy C.C., Yeargin-Allsopp M. Prevalence and descriptive epidemiology of Lennox–Gastaut syndrome among Atlanta children // Epilepsia. — 1997. — V.38, N12. — P.1283–1288.

Wong T.T., Kwan S.Y., Chang K.P. et al. Corpus callosotomy in children // Childs Nerv. Syst. — 2006. — V.22, N8. — P.999–1011.

You S.J., Lee J.K., Ko T.S. Epilepsy surgery in a patient with Lennox–Gastaut syndrome and cortical dysplasia // Brain Dev. — 2007. — V.29, N3. — P.167–170.

Published

2007-12-08

How to Cite

Laponogov, A. O., Tsymbalyuk, V. I., & Kostyuk, K. R. (2007). The surgical treatment improving at Lennox–Gastaut syndrome. Ukrainian Neurosurgical Journal, (4), 31–33. https://doi.org/10.25305/unj.112335

Issue

Section

Original articles