Cyber-knife radiosurgery for spine and spinal cord tumors treatment

Authors

  • Yu. E. Pedachenko National Medical Academy of Postgraduate Education named after P.L. Shupyk of Ministry of Health Care of Ukraine, Kiev, Ukraine

DOI:

https://doi.org/10.25305/unj.108629

Keywords:

tumors of spine, tumors of spinal cord, radiosurgery, Cyber-knife

Abstract

Radiosurgery is a new direction in treatment of different diseases, mainly oncology. After Gamma-knife clinical introduction the search of possibilities for radiosurgical interventions, performing in extracranial areas, including spine and spinal cord, has began. Basic principles of Cyber-knife-radiosurgery in treatment of spine and spinal cord tumors are described. Also an analysis of literature data was made, where results of 971 patients with spinal tumors using Cyber-knife were described.

Taking into consideration novelty of this method (FDA permitted to use Cyber-knife in clinic only in 2001) sufficient follow-up information is absent, but first results are hopeful. Decrease of pain intensity was marked at 84–96% of patients with spinal tumors, local depression of tumor growth — at 75–100% (depending on tumor histological type).

Complications and failures of Cyber-knife radiosurgery are conditioned by continuing tumor growth, neurological and common postradiation disorders.

This review shows that Cyber-knife-radiosurgery is a perspective method for spinal and spinal cord tumors treatment.

References

Adler J.R. Jr.,ChangS.D., Murphy M.J. et al. The Cyberknife: A frameless robotic system for radiosurgery // Stereotactic&Functional Neurosurgery. — 1997. — V.69. — P.124–128.

Adler J.R. Jr.,ColomboF., Heilbrun M.P. et al. Toward an expanded view of radiosurgery // Neurosurgery. — 2004. — V.55. — P.1374–1376.

Andrews D.W., Bednarz G., Evans J.J. et al. A review of 3 current radiosurgery systems // Surg. Neurol. — 2006. — V.66. — P.559–564.

ColomboF., Benedetti A., Pozza F. et al. Extremal stereotactic irradiation by linear accelerator // Neurosurgery. — 1985. — V.16. — P.154–160.

Das I.J., Downes M.B., Corn B.W. et al. Characteristics of a dedicated linear accelerator-based stereotactic radiosurgery-radiotherapy unit // Radiother. Oncol. — 1996. — V.38. — P.61–68.

Degen J.W., Gagnon G.J., Voyadzis J.M. et al. CyberKnife stereotactic radiosurgical treatment of spinal tumors for pain control and quality of life // J. Neurosurg. Spine. — 2005. — V.2, N5. — P.540–549.

Dieterich S., Rodgers J., Chan R. Radiosurgery Image-Guided Interventions / Eds. T. Peters, K. Cleary. — N.Y.: Springer Science; Business Media, LLC, 2008. — Chapter 16. — P.461–500.

Dodd R.I., Ryu M.-R., Kamnerdsupaphon P. et al. CyberKnife radiosurgery for benign intradural extramedullary spinal tumors // Neurosurgery. — 2006. — V.58, N4. — P.674–685.

Gagnon G.J., Henderson F.G., Gehan E.A. et al. CyberKnife radiosurgery for breast cancer spine metastases: a matched-pair analysis // Cancer. — 2007. — V.110, N8. — P.1796–1802.

Gerszten P.C.,BurtonS.A., Ozhasoglu C. et al. Radiosurgery for spinal metastases. Clinical experience in 500 cases from a single institution // Spine. — 2007. — V.32, N2. — P.193–199.

Gerszten P.C.,BurtonS.A., Welch W.C. et al. CyberKnife single-fraction radiosurgery for the treatment of spinal breast metastases // Cancer. — 2005. — V.104. — P.2244–2254.

Gerszten P.C., Germanwala A.,BurtonS.A.et al.Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures // Neurosurg. Focus. — 2005. —V.18. — Art.8.

Gerszten P.C., Ozhasoglu C.,BurtonS.A.et al.Feasibility of frameless single-fraction stereotactic radiosurgery for spinal lesions // Neurosurg. Focus. — 2002. — V.13, N4. — Art.2.

Gerszten P.C., Ozhasoglu C., Burton S.A. et al. CyberKnife frameless single-fraction stereotactic radiosurgery for benign tumors of the spine // Neurosurg. Focus. — 2003. — V.14, N5. — Art.16.

Gerszten P.C., Ozhasoglu C., Burton S.A. et al. CyberKnife frameless single-fraction stereotactic radiosurgery for tumors of the sacrum // Neurosurg. Focus. — 2003. — V.15, N2. — Art.7.

Gibbs I.C., Chang S.D. Radiosurgery and radiotherapy for sacral tumors // Neurosurg. Focus. — 2003. — V.15. — Art.8.

Kuo J.S., Yu C., Petrovich Z. et al. The Cyberknife stereotactic radiosurgery system: Description, anstalation, and an initial evaluation of use and functionality // Neurosurgery. — 2003. — V.53, N5. — P.1235–1239.

Leksell L. The stereotaxic method and radiosurgery of the brain // Acta Chir. Scand. — 1951. — V.102, N4. — P.316–319.

Li G., Patil C., Adler J.R. et al. CyberKnife rhizotomy for facetogenic back pain: a pilot study // Neurosurg Focus. — 2007. — V.23, N6. — E2.

Lunsford L.D., Maitz A., Lindner G. FirstUnited States201 source cobalt-60 gamma unit for radiosurgery // Appl. Neurophysiol. — 1987. — V.50. — P.253–256.

Muacevic A., Wowra B., Reiser M. CyberKnife: review of first 1000 cases at a dedicated therapy center // Int. J. CARS. – 2008. – Vol. 3. – P. 447-456.

Muacevic A., Staehler M., Drexler C. et al. Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery // J. Neurosurg. Spine. — 2006. — V.5, N4. — P.303–312.

Murphy M.J., Adler J.R. Jr., Bodduluri M. et al. Image-guided radiosurgery for the spine and pancreas // Comp. Aid. Surg. — 2000. — V.5, N4. — P.278–288.

Murphy M.J., Chang S.,GibbsI.et al.Image-guided radiosurgery in the treatment of spinal metastases // Neurosurg. Focus. — 2001. — V.11, N6. — Art.6.

Quinn A.M. CyberKnife: A robotic radiosurgery system // Clin. J. Oncol. Nurs. — 2002. — V.6, N3. — P.149–156.

Rock J.P., Ryu S.I., Yin F.-F. et al. The evolving role of stereotactic radiosurgery and stereotactic radiation therapy for patients with spine tumors // J. Neuro-Oncol. — 2004. — V.69. — P.319–334.

Ryu S.I.,ChangS.D., Kim D.H. et al. Image-guided hypo-fractionated stereotactic radiosurgery to spinal lesions // Neurosurgery. — 2001. — V.49, N4. — P.838–846.

Sheehan J.P., Jagannathan J. Review of spinal radiosurgery: a minimally invasive approach for the treatment of spinal and paraspinal metastases // Neurosurg. Focus. — 2008. — V.25, N2. — Art.18.

Steffey-Stacy E.C. Frameless, Image-guided stereotactic radiosurgery // Seminars Oncol. Nurs. — 2006. — V.22, N4. — P.221–232.

Spine radiosurgery / Eds. P.C. Gerszten, S. Ryu. —New York;Stuttgart: Thieme Med. Publ. Inc., 2008. — 158 p.

Wowra B., Zausinger S., Drexler C. et al. CyberKnife radiosurgery for malignant spinal tumors. Characterization of well-suited patients // Spine. — 2008. — V.33, N26. — P.2929–2934.

Published

2009-06-12

How to Cite

Pedachenko, Y. E. (2009). Cyber-knife radiosurgery for spine and spinal cord tumors treatment. Ukrainian Neurosurgical Journal, (2), 4–9. https://doi.org/10.25305/unj.108629

Issue

Section

Review articles